TY - JOUR
T1 - Fibroblast growth factor signaling is essential for self-renewal of dental epithelial stem cells
AU - Chang, Julia Yu Fong
AU - Wang, Cong
AU - Liu, Junchen
AU - Huang, Yanqing
AU - Jin, Chengliu
AU - Yang, Chaofeng
AU - Hai, Bo
AU - Liu, Fei
AU - D'Souza, Rena N.
AU - McKeehan, Wallace L.
AU - Wang, Fen
PY - 2013/10/4
Y1 - 2013/10/4
N2 - Background:Understanding of the self-renewal and differentiation of dental epithelial stem cells (DESCs) is important for tooth regeneration therapies. Results:Depletion of FGF signaling suppressed self-renewal and led to differentiation of DESCs. Conclusion:FGF signaling is essential for maintenance of DESCs. Significance:The finding sheds new light on the mechanism by which the homeostasis, expansion, and differentiation of DESCs are regulated.
AB - Background:Understanding of the self-renewal and differentiation of dental epithelial stem cells (DESCs) is important for tooth regeneration therapies. Results:Depletion of FGF signaling suppressed self-renewal and led to differentiation of DESCs. Conclusion:FGF signaling is essential for maintenance of DESCs. Significance:The finding sheds new light on the mechanism by which the homeostasis, expansion, and differentiation of DESCs are regulated.
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U2 - 10.1074/jbc.M113.506873
DO - 10.1074/jbc.M113.506873
M3 - Article
C2 - 23979135
AN - SCOPUS:84885170786
SN - 0021-9258
VL - 288
SP - 28952
EP - 28961
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 40
ER -