Fibroblast growth factor (FGF) homologous factors: New members of the FGF family implicated in nervous system development

Philip M. Smallwood, Ignacio Munoz-Sanjuan, Patrick Tong, Jennifer P. Macke, Stewart H.C. Hendry, Debra J. Gilbert, Neal G. Copeland, Nancy A. Jenkins, Jeremy Nathans

Research output: Contribution to journalArticle

308 Scopus citations

Abstract

Four new members of the fibroblast growth factor (FGF) family, referred to as fibroblast growth factor homologous factors (FHFs), have been identified by a combination of random cDNA sequencing, data base searches, and degenerate PCR. Pairwise comparisons between the four FHFs show between 58% and 71% amino acid sequence identity, but each FHF shows less than 30% identity when compared with other FGFs. Like FGF-1 (acidic FGF) and FGF-2 {basic FGF), the FHFs lack a classical signal sequence and contain clusters of basic residues that can act as nuclear localization signals. In transiently transfected 293 cells FHF-1 accumulates in the nucleus and is not secreted. Each FHF is expressed in the developing and adult nervous systems, suggesting a role for this branch of the FGF family in nervous system development and function.

Original languageEnglish (US)
Pages (from-to)9850-9857
Number of pages8
JournalProceedings of the National Academy of Sciences of the United States of America
Volume93
Issue number18
DOIs
StatePublished - Sep 3 1996

ASJC Scopus subject areas

  • General

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