TY - JOUR
T1 - Fibrinogen-binding proteins of Gram-positive bacteria
AU - Rivera, Jose
AU - Vannakambadi, Ganesh
AU - Höök, Magnus
AU - Speziale, Pietro
N1 - Copyright:
Copyright 2009 Elsevier B.V., All rights reserved.
PY - 2007/9
Y1 - 2007/9
N2 - Fibrinogen (Fg), the major clotting protein in blood plasma, plays key roles in blood coagulation and thrombosis. In addition, this 340 kD glycoprotein is a stress inducible protein; its synthesis is dramatically upregulated during inflammation or under exposure to stress such systemic infections. This regulation of Fg expression indicates that Fg also participates in the host defense system against infections, In fact, a number of reported studies have demonstrated the involvement of both the intrinsic and extrinsic pathways of coagulation; the thrombotic and the fibrinolytic systems in the pathophysiology of infectious diseases. It is, therefore, perhaps not surprising that many pathogenic bacteria can interact with Fg and manipulate its biology.This review focuses on the major Fg-binding proteins (Fgbps) from Gram-positive bacteria with an emphasis on those that are known to have an effect on coagulation and thrombosis.
AB - Fibrinogen (Fg), the major clotting protein in blood plasma, plays key roles in blood coagulation and thrombosis. In addition, this 340 kD glycoprotein is a stress inducible protein; its synthesis is dramatically upregulated during inflammation or under exposure to stress such systemic infections. This regulation of Fg expression indicates that Fg also participates in the host defense system against infections, In fact, a number of reported studies have demonstrated the involvement of both the intrinsic and extrinsic pathways of coagulation; the thrombotic and the fibrinolytic systems in the pathophysiology of infectious diseases. It is, therefore, perhaps not surprising that many pathogenic bacteria can interact with Fg and manipulate its biology.This review focuses on the major Fg-binding proteins (Fgbps) from Gram-positive bacteria with an emphasis on those that are known to have an effect on coagulation and thrombosis.
KW - Bacteria
KW - Bacterial infection
KW - Fibrinogen/fibrin
KW - Infectious diseases
KW - Protein function/activity
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U2 - 10.1160/TH07-03-0233
DO - 10.1160/TH07-03-0233
M3 - Review article
C2 - 17849038
AN - SCOPUS:34548668908
SN - 0340-6245
VL - 98
SP - 503
EP - 511
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
IS - 3
ER -