Fever and reversible laboratory abnormalities associated with prolonged use of piperacillin-tazobactam in children

Aesha Patel; Kuo Rei Mao; J. Chase Mcneil; Sheldon L. Kaplan; Jesus G. Vallejo

doi:10.1097/INF.0000000000000748

Fever and reversible laboratory abnormalities associated with prolonged use of piperacillin-tazobactam in children

Aesha Patel, Kuo Rei Mao, J. Chase Mcneil, Sheldon L. Kaplan, Jesus G. Vallejo

Houston Methodist

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Piperacillin-tazobactam is used frequently in pediatric patients with complicated appendicitis and other intra-abdominal infections. We report 10 pediatric patients who developed a piperacillin-tazobactam-associated adverse reaction characterized by fever, rash, hematologic abnormalities and transaminitis. Physicians should be aware of this entity in patients treated with a prolonged course of piperacillin-tazobactam. Prompt identification can obviate unnecessary diagnostic testing and treatment.

Original language	English (US)
Pages (from-to)	849-850
Number of pages	2
Journal	Pediatric Infectious Disease Journal
Volume	34
Issue number	8
DOIs	https://doi.org/10.1097/INF.0000000000000748
State	Published - Aug 21 2015

Keywords

Piperacillin-tazobactam
adverse drug reaction
pediatrics

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

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10.1097/INF.0000000000000748

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AU - Kaplan, Sheldon L.

AU - Vallejo, Jesus G.

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AB - Piperacillin-tazobactam is used frequently in pediatric patients with complicated appendicitis and other intra-abdominal infections. We report 10 pediatric patients who developed a piperacillin-tazobactam-associated adverse reaction characterized by fever, rash, hematologic abnormalities and transaminitis. Physicians should be aware of this entity in patients treated with a prolonged course of piperacillin-tazobactam. Prompt identification can obviate unnecessary diagnostic testing and treatment.

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Fever and reversible laboratory abnormalities associated with prolonged use of piperacillin-tazobactam in children

Abstract

Keywords

ASJC Scopus subject areas

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