TY - GEN
T1 - Feature selection and classification of pro-TOF data based on soft information
AU - Zhang, Lin
AU - Zhang, Jian Qiu
AU - Zhou, Xiao Bo
AU - Wang, Hong Hui
AU - Huang, Yu Fei
AU - Liu, Hui
AU - Wong, Stephen
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2008
Y1 - 2008
N2 - In this paper, we introduce a feature selection and classification method for prOTOF Mass Spectrometry (MS) data profiles of diseased and healthy patients. The method is based on a special statistical measure, which quantifies the probability of the existence of peptidepeaks. A special ranking score that is based on the statistical measure is used for selecting features that can best distinguish diseased and healthy data profiles. Based on the selected features, we applied a variety of classification algorithms and the results are compared with that of a method which selects features only based on peak heights. The results show a significant improvement in classification error rate with our proposed method.
AB - In this paper, we introduce a feature selection and classification method for prOTOF Mass Spectrometry (MS) data profiles of diseased and healthy patients. The method is based on a special statistical measure, which quantifies the probability of the existence of peptidepeaks. A special ranking score that is based on the statistical measure is used for selecting features that can best distinguish diseased and healthy data profiles. Based on the selected features, we applied a variety of classification algorithms and the results are compared with that of a method which selects features only based on peak heights. The results show a significant improvement in classification error rate with our proposed method.
UR - http://www.scopus.com/inward/record.url?scp=57749113709&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57749113709&partnerID=8YFLogxK
U2 - 10.1109/ICMLC.2008.4621105
DO - 10.1109/ICMLC.2008.4621105
M3 - Conference contribution
AN - SCOPUS:57749113709
SN - 9781424420964
T3 - Proceedings of the 7th International Conference on Machine Learning and Cybernetics, ICMLC
SP - 4018
EP - 4023
BT - Proceedings of the 7th International Conference on Machine Learning and Cybernetics, ICMLC
T2 - 7th International Conference on Machine Learning and Cybernetics, ICMLC
Y2 - 12 July 2008 through 15 July 2008
ER -