Feasibility of image-guided transthoracic core-needle biopsy in the BATTLE lung trial

Alda L. Tam, Edward S. Kim, J. Jack Lee, Joe E. Ensor, Marshall E. Hicks, Ximing Tang, George R. Blumenschein, Christine M. Alden, Jeremy J. Erasmus, Anne Tsao, Scott M. Lippman, Waun K. Hong, Ignacio I. Wistuba, Sanjay Gupta

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

BACKGROUND: As therapy for non-small-cell lung cancer (NSCLC) patients becomes more personalized, additional tissue in the form of core-needle biopsies (CNBs) for biomarker analysis is increasingly required for determining appropriate treatment and for enrollment into clinical trials. We report our experience with small-caliber percutaneous transthoracic (PT) CNBs for the evaluation of multiple molecular biomarkers in BATTLE (biomarker-integrated approaches of targeted therapy for lung cancer elimination), a personalized, targeted therapy NSCLC clinical trial. METHODS: The medical records of patients who underwent PTCNB for consideration of enrollment in BATTLE were reviewed for diagnostic yield of 11 predetermined molecular markers and procedural complications. Univariate and multivariate analyses of factors related to patient and lesion characteristics were performed to determine possible influences on diagnostic yield. RESULTS: One hundred and seventy PTCNBs were performed using 20-gauge biopsy needles in 151 NSCLC patients screened for the trial. The biopsy specimens of 82.9% of the patients were found to have adequate tumor tissue for analysis of the required biomarkers. On multivariate analysis, metastatic lesions were 5.4 times more likely to yield diagnostic tissue as compared with primary tumors (p = 0.0079). Pneumothorax and chest tube insertion rates were 15.3% and 9.4%, respectively. CONCLUSIONS: Image-guided 20-gauge PTCNB is safe and provides adequate tissue for analysis of multiple biomarkers in the majority of patients being considered for enrollment into a personalized, targeted therapy NSCLC clinical trial. Metastatic lesions are more likely to yield diagnostic tissue as compared with primary tumors.

Original languageEnglish (US)
Pages (from-to)436-442
Number of pages7
JournalJournal of Thoracic Oncology
Volume8
Issue number4
DOIs
StatePublished - Apr 2013

Keywords

  • Biomarker analysis
  • Percutaneous transthoracic biopsy
  • Research biopsy

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

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