Fatal hepatitis B reactivation after autologous bone marrow transplantation

A. Webster, M. K. Brenner, H. G. Prentice, P. D. Griffiths

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

We report a fatal case of hepatitis B reactivation following autologous bone marrow transplantation for acute lymphocytic leukaemia. The presence of antibodies to HBs and HBc at presentation indicated previous infection with hepatitis B; these antibodies disappeared during the course of treatment for leukaemia. HBsAg was first detected in serum 5 weeks post-transplant; liver function tests began to deteriorate 8 weeks later, when HBeAg was first detected. The hepatitis followed a fulminant course, and the patient died 10 days later, in the 15th week following transplant.

Original languageEnglish (US)
Pages (from-to)207-208
Number of pages2
JournalBone Marrow Transplantation
Volume4
Issue number2
StatePublished - 1989

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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