Fatal diffuse alveolar damage associated with oxaliplatin administration

Jack Watkins, Julian H. Slade, Alex Phan, Cathy Eng, Annikka Weissferdt, Michael J. Overman

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Oxaliplatin-based chemotherapy regimens are currently a standard of care for the treatment of colorectal cancer in both the adjuvant and metastatic disease settings. Significant improvements in survival have resulted from the use of oxaliplatin-based combinations. This article describes the use of oxaliplatin-based chemotherapy in a patient with stage III colon cancer who developed fatal diffuse alveolar damage during his adjuvant therapy. Other cases of pulmonary toxicity associated with oxaliplatin use are presented and the proposed pathophysiology of this rare occurrence is discussed.

Original languageEnglish (US)
Pages (from-to)198-202
Number of pages5
JournalClinical colorectal cancer
Issue number3
StatePublished - Sep 2011


  • Diffuse alveolar damage
  • Eosinophilia
  • Oxaliplatin

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology


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