Fatal cerebral venous thrombosis as the initial manifestation of the antiphospholipid syndrome

Ramtin Agah; Lawrence Rice; John Winikates

doi:10.1016/0303-8467(96)00006-6

Fatal cerebral venous thrombosis as the initial manifestation of the antiphospholipid syndrome

Ramtin Agah, Lawrence Rice, John Winikates

Research output: Contribution to journal › Article

9 Scopus citations

Abstract

We describe a patient with cerebral venous thrombosis (CVT) who presented with thrombocytopenia and persistent headache. The etiology of her CVT was determined to be the antiphospholipid syndrome (APLS) based on a prolonged dilute Russell viper venom test and elevated anti-cardiolipin IgG antibody. CVT has rarely been reported as the initial manifestation of the APLS. Despite supportive measures and anticoagulation, the patient expired. Clinicians should consider the possibility of CVT when coagulation abnormalities consistent with APLS are combined with neurologic symptoms. Early detection and treatment are crucial for a favorable outcome.

Original language	English (US)
Pages (from-to)	189-191
Number of pages	3
Journal	Clinical Neurology and Neurosurgery
Volume	98
Issue number	2
DOIs	https://doi.org/10.1016/0303-8467(96)00006-6
State	Published - Jan 1 1996

Keywords

Anti-phospholipid antibody
Cerebral venous thrombosis
Venous stroke

ASJC Scopus subject areas

Clinical Neurology
Surgery
Neurology

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abstract = "We describe a patient with cerebral venous thrombosis (CVT) who presented with thrombocytopenia and persistent headache. The etiology of her CVT was determined to be the antiphospholipid syndrome (APLS) based on a prolonged dilute Russell viper venom test and elevated anti-cardiolipin IgG antibody. CVT has rarely been reported as the initial manifestation of the APLS. Despite supportive measures and anticoagulation, the patient expired. Clinicians should consider the possibility of CVT when coagulation abnormalities consistent with APLS are combined with neurologic symptoms. Early detection and treatment are crucial for a favorable outcome.",

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AB - We describe a patient with cerebral venous thrombosis (CVT) who presented with thrombocytopenia and persistent headache. The etiology of her CVT was determined to be the antiphospholipid syndrome (APLS) based on a prolonged dilute Russell viper venom test and elevated anti-cardiolipin IgG antibody. CVT has rarely been reported as the initial manifestation of the APLS. Despite supportive measures and anticoagulation, the patient expired. Clinicians should consider the possibility of CVT when coagulation abnormalities consistent with APLS are combined with neurologic symptoms. Early detection and treatment are crucial for a favorable outcome.

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