Fat emulsion infusion potentiates coagulation activation during human endotoxemia

Tom Van Der Poll, Susette M. Coyle, Marcel Levi, Marja A. Boermeester, Carla C. Braxton, Patty M. Jansen, C. Erik Hack, Stephen F. Lowry

Research output: Contribution to journalArticlepeer-review

Abstract

Intravenous fat emulsions are frequently given to malnourished patients who are prone to suffer from infectious complications. As injection of low dose endotoxin represents a model to study the human response to acute infection, we sought to determine the effect of lipid emulsion infusion on endotoxin-induced activation of the hemostatic mechanism in man. Ten healthy men received a bolus intravenous injection of endotoxin (lot EC-5; 20 U/kg) midway through a 4-h infusion (125 ml/h) of either dextrose 5% (n = 5) or Intralipid 20% (n = 5). Lipid infusion potentiated endotoxin-induced coagulation activation, as indicated by higher plasma levels of the prothrombin fragment F1 + 2 and of thrombin-antithrombin III complexes (both p < 0.05 for the difference between groups). However, lipid infusion did not influence the fibrinolytic response to intravenous endotoxin, as reflected by similar increases in the levels of tissue-type plasminogen activator and plasmin-α2-antiplasmin complexes in both groups. Endotoxin-induced appearance of plasminogen activator inhibitor type I was enhanced by lipid infusion (p < 0.05). These data suggest that fat emulsion infusion may enhance the tendency towards thrombotic complications in patients with infections.

Original languageEnglish (US)
Pages (from-to)83-86
Number of pages4
JournalThrombosis and Haemostasis
Volume75
Issue number1
DOIs
StatePublished - Jan 1996

ASJC Scopus subject areas

  • Hematology

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