TY - JOUR
T1 - Fasting mediated increase in p-BADser155 and p-AKTser473 in the prefrontal cortex of mice
AU - Pitchaimani, Vigneshwaran
AU - Arumugam, Somasundaram
AU - Thandavarayan, Rajarajan Amirthalingam
AU - Karuppagounder, Vengadeshprabhu
AU - Sreedhar, Remya
AU - Afrin, Rejina
AU - Harima, Meilei
AU - Suzuki, Hiroshi
AU - Miyashita, Shizuka
AU - Nomoto, Mayumi
AU - Sone, Hirohito
AU - Suzuki, Kenji
AU - Watanabe, Kenichi
N1 - Funding Information:
This research was supported by Ministry of Education, Culture, Sports, Science, and Technology , Japan, and by a grant from the promotion and mutual aid corporation for Private schools, Japan ( 23602012 and 26460239 ) respectively. The authors have no conflict of interest.
PY - 2014/9/5
Y1 - 2014/9/5
N2 - BAD-deficient mice and fasting have several common functional roles in seizures, beta-hydroxybutyrate (BHB) uptake in brain and alteration in counterregulatory hormonal regulation during hypoglycemia. Neuronal specific insulin receptor knockout (NIRKO) mice display impaired counterregulatory hormonal responses during hypoglycemia. In this study we investigated the fasting mediated expression of p-BADser155 and p-AKTser473 in different regions of brain (prefrontal cortex, hippocampus, midbrain and hypothalamus). Fasting specifically increases p-BADser155 and p-AKTser473 in prefrontal cortex and decreases in other regions of brain. Our results suggest that fasting may increase the uptake BHB by decreasing p-BADser155 in the brain during hypoglycemia except prefrontal cortex and it uncovers specific functional area of p-BADser155 and p-AKTser473 that may regulates counter regulatory hormonal response. Overall in support with previous findings, fasting mediated hypoglycemia activates prefrontal cortex insulin signaling which influences the hypothalamic paraventricular nucleus mediated activation of sympathoadrenal hormonal responses.
AB - BAD-deficient mice and fasting have several common functional roles in seizures, beta-hydroxybutyrate (BHB) uptake in brain and alteration in counterregulatory hormonal regulation during hypoglycemia. Neuronal specific insulin receptor knockout (NIRKO) mice display impaired counterregulatory hormonal responses during hypoglycemia. In this study we investigated the fasting mediated expression of p-BADser155 and p-AKTser473 in different regions of brain (prefrontal cortex, hippocampus, midbrain and hypothalamus). Fasting specifically increases p-BADser155 and p-AKTser473 in prefrontal cortex and decreases in other regions of brain. Our results suggest that fasting may increase the uptake BHB by decreasing p-BADser155 in the brain during hypoglycemia except prefrontal cortex and it uncovers specific functional area of p-BADser155 and p-AKTser473 that may regulates counter regulatory hormonal response. Overall in support with previous findings, fasting mediated hypoglycemia activates prefrontal cortex insulin signaling which influences the hypothalamic paraventricular nucleus mediated activation of sympathoadrenal hormonal responses.
KW - AKT
KW - BAD
KW - Betahydroxybutyrate
KW - Fasting
KW - Hypoglycemia
KW - Prefrontal cortex
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U2 - 10.1016/j.neulet.2014.07.009
DO - 10.1016/j.neulet.2014.07.009
M3 - Article
C2 - 25043191
AN - SCOPUS:84905488031
VL - 579
SP - 134
EP - 139
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
ER -