Familial retinoblastoma: Where and when?

David H. Abramson, Mary E. Mendelsohn, Camille A. Servodidio, Theresa Tretter, Dan S. Gombos

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Purpose: To determine when patients with a family history of retinoblastoma and previously normal eye exam develop intraocular disease, and where the new retinoblastoma tumors occur. Methods: A retrospective chart review of retinoblastoma patients. Results: Sixty-two percent of the first eyes (eyes having a previously normal examination) were diagnosed with retinoblastoma by 6 months of age, 90% by 12 months and 100% by 28 months. For the second eye, 27% were identified by 6 months, 64% by 12 months, 91% by 30 months and 100% by 44 months. The younger the age at initial diagnosis of retinoblastoma, the greater the likelihood that tumors will initially be found in the posterior pole. Macular tumors were diagnosed very early (mean 4 months) and once a retinoblastoma focus had appeared in one eye no new tumors developed in the macula of either eye. Conclusion: The timing, location, and number of new retinoblastoma tumors follows a predictable pattern.

Original languageEnglish (US)
Pages (from-to)334-338
Number of pages5
JournalActa Ophthalmologica Scandinavica
Issue number3
StatePublished - Jun 1998


  • Cancer
  • Eye
  • Familial
  • Germinal
  • Pediatric
  • RB1 mutation
  • Retina
  • Retinoblastoma
  • Tumors

ASJC Scopus subject areas

  • Ophthalmology


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