Familial Occurrence of Primary Sclerosing Cholangitis and Ulcerative Colitis

E. M.M. Quigley, N. F. LaRusso, J. Ludwig, R. N.M. MacSween, G. G. Birnie, G. Watkinson

Research output: Contribution to journalArticle

111 Scopus citations

Abstract

Members of three families had primary sclerosing cholangitis and chronic ulcerative colitis. In each family, 2 siblings were affected; in one instance, they were twin brothers. All 6 individuals had primary sclerosing cholangitis and 5 also had ulcerative colitis. These cases represent the first reported instances of the familial occurrence of both primary sclerosing cholangitis and chronic ulcerative colitis; illustrate the typical clinical, laboratory, radiologic, and pathological features of primary sclerosing cholangitis; and support the hypothesis that genetic factors may play a role in the etiology of this obscure disorder.

Original languageEnglish (US)
Pages (from-to)1160-1165
Number of pages6
JournalGastroenterology
Volume85
Issue number5
DOIs
StatePublished - 1983

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'Familial Occurrence of Primary Sclerosing Cholangitis and Ulcerative Colitis'. Together they form a unique fingerprint.

Cite this