Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer

Pengyuan Liu; Haris G. Vikis; Daolong Wang; Yan Lu; Yian Wang; Ann G. Schwartz; Susan M. Pinney; Ping Yang; Mariza De Andrade; Gloria M. Petersen; Jonathan S. Wiest; Pamela R. Fain; Adi Gazdar; Colette Gaba; Henry Rothschild; Diptasri Mandal; Teresa Coons; Juwon Lee; Elena Kupert; Daniela Seminara; John Minna; Joan E. Bailey-Wilson; Xifeng Wu; Margaret R. Spitz; Timothy Eisen; Richard S. Houlston; Christopher I. Amos; Marshall W. Anderson; Ming You

doi:10.1093/jnci/djn268

Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer

Pengyuan Liu, Haris G. Vikis, Daolong Wang, Yan Lu, Yian Wang, Ann G. Schwartz, Susan M. Pinney, Ping Yang, Mariza De Andrade, Gloria M. Petersen, Jonathan S. Wiest, Pamela R. Fain, Adi Gazdar, Colette Gaba, Henry Rothschild, Diptasri Mandal, Teresa Coons, Juwon Lee, Elena Kupert, Daniela SeminaraJohn Minna, Joan E. Bailey-Wilson, Xifeng Wu, Margaret R. Spitz, Timothy Eisen, Richard S. Houlston, Christopher I. Amos, Marshall W. Anderson, Ming You

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

Abstract

Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted.

Original language	English (US)
Pages (from-to)	1326-1330
Number of pages	5
Journal	Journal of the National Cancer Institute
Volume	100
Issue number	18
DOIs	https://doi.org/10.1093/jnci/djn268
State	Published - Sep 2008

ASJC Scopus subject areas

Oncology
Cancer Research

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Liu, P., Vikis, H. G., Wang, D., Lu, Y., Wang, Y., Schwartz, A. G., Pinney, S. M., Yang, P., De Andrade, M., Petersen, G. M., Wiest, J. S., Fain, P. R., Gazdar, A., Gaba, C., Rothschild, H., Mandal, D., Coons, T., Lee, J., Kupert, E., ... You, M. (2008). Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. Journal of the National Cancer Institute, 100(18), 1326-1330. https://doi.org/10.1093/jnci/djn268

Liu, P, Vikis, HG, Wang, D, Lu, Y, Wang, Y, Schwartz, AG, Pinney, SM, Yang, P, De Andrade, M, Petersen, GM, Wiest, JS, Fain, PR, Gazdar, A, Gaba, C, Rothschild, H, Mandal, D, Coons, T, Lee, J, Kupert, E, Seminara, D, Minna, J, Bailey-Wilson, JE, Wu, X, Spitz, MR, Eisen, T, Houlston, RS, Amos, CI, Anderson, MW & You, M 2008, 'Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer', Journal of the National Cancer Institute, vol. 100, no. 18, pp. 1326-1330. https://doi.org/10.1093/jnci/djn268

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title = "Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer",

abstract = "Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted.",

author = "Pengyuan Liu and Vikis, {Haris G.} and Daolong Wang and Yan Lu and Yian Wang and Schwartz, {Ann G.} and Pinney, {Susan M.} and Ping Yang and {De Andrade}, Mariza and Petersen, {Gloria M.} and Wiest, {Jonathan S.} and Fain, {Pamela R.} and Adi Gazdar and Colette Gaba and Henry Rothschild and Diptasri Mandal and Teresa Coons and Juwon Lee and Elena Kupert and Daniela Seminara and John Minna and Bailey-Wilson, {Joan E.} and Xifeng Wu and Spitz, {Margaret R.} and Timothy Eisen and Houlston, {Richard S.} and Amos, {Christopher I.} and Anderson, {Marshall W.} and Ming You",

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doi = "10.1093/jnci/djn268",

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AU - Liu, Pengyuan

AU - Vikis, Haris G.

AU - Wang, Daolong

AU - Lu, Yan

AU - Wang, Yian

AU - Schwartz, Ann G.

AU - Pinney, Susan M.

AU - Yang, Ping

AU - De Andrade, Mariza

AU - Petersen, Gloria M.

AU - Wiest, Jonathan S.

AU - Fain, Pamela R.

AU - Gazdar, Adi

AU - Gaba, Colette

AU - Rothschild, Henry

AU - Mandal, Diptasri

AU - Coons, Teresa

AU - Lee, Juwon

AU - Kupert, Elena

AU - Seminara, Daniela

AU - Minna, John

AU - Bailey-Wilson, Joan E.

AU - Wu, Xifeng

AU - Spitz, Margaret R.

AU - Eisen, Timothy

AU - Houlston, Richard S.

AU - Amos, Christopher I.

AU - Anderson, Marshall W.

AU - You, Ming

PY - 2008/9

Y1 - 2008/9

N2 - Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted.

AB - Three recent genome-wide association studies identified associations between markers in the chromosomal region 15q24-25.1 and the risk of lung cancer. We conducted a genome-wide association analysis to investigate associations between single-nucleotide polymorphisms (SNPs) and the risk of lung cancer, in which we used blood DNA from 194 case patients with familial lung cancer and 219 cancer-free control subjects. We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. The risk of lung cancer was more than fivefold higher among those subjects who had both a family history of lung cancer and two copies of high-risk alleles rs8034191 (odds ratio [OR] = 7.20, 95% confidence interval [CI] = 2.21 to 23.37) or rs1051730 (OR = 5.67, CI = 2.21 to 14.60, both of which were located in the 15q24-25.1 locus, than among control subjects. Thus, further research to elucidate causal variants in the 15q24-25.1 locus that are associated with lung cancer is warranted.

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JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

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ER -

Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer

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