False-positive lesions mimicking breast cancer on FDG PET and PET/CT

Margaret Adejolu, Lei Huo, Eric M. Rohren, Lumarie Santiago, Wei T. Yang

Research output: Contribution to journalReview articlepeer-review

96 Scopus citations


OBJECTIVE. Incidental 18F-FDG-avid breast lesions are commonly encountered in patients with cancer who undergo staging PET/CT. This pictorial essay discusses breast lesions that show increased FDG activity, mimicking breast cancer, with biopsy-confirmed benign diagnosis. CONCLUSION. Acute and chronic inflammation, physiologic lactation, and benign breast masses, including silicone granuloma, fat necrosis, fibroadenoma, and postsurgical changes, may show increased FDG uptake on PET/CT. These conditions can often be differentiated from malignancy by correlative imaging, including mammography, sonography, or MRI.

Original languageEnglish (US)
JournalAmerican Journal of Roentgenology
Issue number3
StatePublished - Mar 1 2012


  • Breast
  • Mammography
  • Neoplasm
  • PET/CT
  • Ultrasound

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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