Failure to induce chimerism or tolerance in mice with monoclonal anti-T cell antibodies plus allogeneic bone marrow infusion

H. Auchincloss, R. R.M. Ghobrial, S. Shea, R. N. Pierson, H. J. Winn

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Monoclonal anti-T cell antibodies have been used successfully in vivo to suppress many immune responses. In humans, OKT3 has been shown to be a potent agent for the reversal of acute rejection. In mice, monoclonal antibodies have been used to suppress T-dependent B cell responses and to prolong skin graft survival. Based on this experience, experiments were performed to examine whether allogeneic bone marrow chimeras might be created using monoclonal anti-T cell antibodies in vivo to replace whole body irradiation.

Original languageEnglish (US)
Pages (from-to)1190-1193
Number of pages4
JournalTransplantation Proceedings
Volume20
Issue number6
StatePublished - 1988

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Fingerprint Dive into the research topics of 'Failure to induce chimerism or tolerance in mice with monoclonal anti-T cell antibodies plus allogeneic bone marrow infusion'. Together they form a unique fingerprint.

Cite this