Failure of high-dose daptomycin for bacteremia caused by daptomycin-susceptible enterococcus faecium harboring liasr substitutions

Jose M. Munita; Nagendra N. Mishra; Danya Alvarez; Truc T. Tran; Lorena Diaz; Diana Panesso; Jinnethe Reyes; Barbara E. Murray; Javier A. Adachi; Arnold S. Bayer; Cesar A. Arias

doi:10.1093/cid/ciu642

Failure of high-dose daptomycin for bacteremia caused by daptomycin-susceptible enterococcus faecium harboring liasr substitutions

Jose M. Munita, Nagendra N. Mishra, Danya Alvarez, Truc T. Tran, Lorena Diaz, Diana Panesso, Jinnethe Reyes, Barbara E. Murray, Javier A. Adachi, Arnold S. Bayer, Cesar A. Arias

Houston Methodist

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

High-dose daptomycin (DAP) therapy failed in a neutropenic patient with bloodstream infection caused by a DAP-susceptible Enterococcus faecium (minimum inhibitory concentration, 3 μg/mL) harboring genetic changes associated with DAP resistance, with persistent bacteremia and selection of additional resistances. Daptomycin monotherapy should be used cautiously against DAP-susceptible E. faecium strains with minimum inhibitory concentrations 2 g/mL.

Original language	English (US)
Pages (from-to)	1277-1280
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	59
Issue number	9
DOIs	https://doi.org/10.1093/cid/ciu642
State	Published - Nov 1 2014

Keywords

Daptomycin
Enterococcus faecium
resistance
treatment failure

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

Divisions

Infectious Disease

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10.1093/cid/ciu642

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Munita, J. M., Mishra, N. N., Alvarez, D., Tran, T. T., Diaz, L., Panesso, D., Reyes, J., Murray, B. E., Adachi, J. A., Bayer, A. S., & Arias, C. A. (2014). Failure of high-dose daptomycin for bacteremia caused by daptomycin-susceptible enterococcus faecium harboring liasr substitutions. Clinical Infectious Diseases, 59(9), 1277-1280. https://doi.org/10.1093/cid/ciu642

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abstract = "High-dose daptomycin (DAP) therapy failed in a neutropenic patient with bloodstream infection caused by a DAP-susceptible Enterococcus faecium (minimum inhibitory concentration, 3 μg/mL) harboring genetic changes associated with DAP resistance, with persistent bacteremia and selection of additional resistances. Daptomycin monotherapy should be used cautiously against DAP-susceptible E. faecium strains with minimum inhibitory concentrations 2 g/mL.",

keywords = "Daptomycin, Enterococcus faecium, resistance, treatment failure",

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doi = "10.1093/cid/ciu642",

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AU - Munita, Jose M.

AU - Mishra, Nagendra N.

AU - Alvarez, Danya

AU - Tran, Truc T.

AU - Diaz, Lorena

AU - Panesso, Diana

AU - Reyes, Jinnethe

AU - Murray, Barbara E.

AU - Adachi, Javier A.

AU - Bayer, Arnold S.

AU - Arias, Cesar A.

PY - 2014/11/1

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KW - Daptomycin

KW - Enterococcus faecium

KW - resistance

KW - treatment failure

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Failure of high-dose daptomycin for bacteremia caused by daptomycin-susceptible enterococcus faecium harboring liasr substitutions

Abstract

Keywords

ASJC Scopus subject areas

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