Failure of daptomycin monotherapy for endocarditis caused by an Enterococcus faecium strain with vancomycin-resistant and vancomycin-susceptible subpopulations and evidence of in vivo loss of the vanA gene cluster

Cesar A. Arias; Harrys A. Torres; Kavindra Singh; Diana Panesso; Judson Moore; Audrey Wanger; Barbara E. Murray

doi:10.1086/522656

Failure of daptomycin monotherapy for endocarditis caused by an Enterococcus faecium strain with vancomycin-resistant and vancomycin-susceptible subpopulations and evidence of in vivo loss of the vanA gene cluster

Cesar A. Arias, Harrys A. Torres, Kavindra Singh, Diana Panesso, Judson Moore, Audrey Wanger, Barbara E. Murray

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

A patient with native valve endocarditis caused by a vancomycin "heteroresistant" strain of Enterococcus faecium experienced failure of daptomycin monotherapy without evidence of daptomycin resistance. The infecting organism exhibited in vivo emergence of a vancomycin-susceptible subpopulation lacking vanA. Treatment with a combination of high-dose daptomycin, gentamicin, and high-dose ampicillin cleared the infection.

Original language	English (US)
Pages (from-to)	1343-1346
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	45
Issue number	10
DOIs	https://doi.org/10.1086/522656
State	Published - Nov 15 2007

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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Arias, C. A., Torres, H. A., Singh, K., Panesso, D., Moore, J., Wanger, A., & Murray, B. E. (2007). Failure of daptomycin monotherapy for endocarditis caused by an Enterococcus faecium strain with vancomycin-resistant and vancomycin-susceptible subpopulations and evidence of in vivo loss of the vanA gene cluster. Clinical Infectious Diseases, 45(10), 1343-1346. https://doi.org/10.1086/522656

Failure of daptomycin monotherapy for endocarditis caused by an Enterococcus faecium strain with vancomycin-resistant and vancomycin-susceptible subpopulations and evidence of in vivo loss of the vanA gene cluster. / Arias, Cesar A.; Torres, Harrys A.; Singh, Kavindra et al.
In: Clinical Infectious Diseases, Vol. 45, No. 10, 15.11.2007, p. 1343-1346.

Research output: Contribution to journal › Article › peer-review

Arias, CA, Torres, HA, Singh, K , Panesso, D, Moore, J, Wanger, A & Murray, BE 2007, 'Failure of daptomycin monotherapy for endocarditis caused by an Enterococcus faecium strain with vancomycin-resistant and vancomycin-susceptible subpopulations and evidence of in vivo loss of the vanA gene cluster', Clinical Infectious Diseases, vol. 45, no. 10, pp. 1343-1346. https://doi.org/10.1086/522656

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title = "Failure of daptomycin monotherapy for endocarditis caused by an Enterococcus faecium strain with vancomycin-resistant and vancomycin-susceptible subpopulations and evidence of in vivo loss of the vanA gene cluster",

abstract = "A patient with native valve endocarditis caused by a vancomycin {"}heteroresistant{"} strain of Enterococcus faecium experienced failure of daptomycin monotherapy without evidence of daptomycin resistance. The infecting organism exhibited in vivo emergence of a vancomycin-susceptible subpopulation lacking vanA. Treatment with a combination of high-dose daptomycin, gentamicin, and high-dose ampicillin cleared the infection.",

author = "Arias, \{Cesar A.\} and Torres, \{Harrys A.\} and Kavindra Singh and Diana Panesso and Judson Moore and Audrey Wanger and Murray, \{Barbara E.\}",

note = "Funding Information: Financial support. D.P. was partially funded by a graduate scholarship from The Instituto Colombiano para el Desarrollo de la Ciencia y Tec-nolog{\'i}a, “Francisco Jos{\'e} de Caldas,” Colciencias. National Institute of Allergy and Infectious Diseases (T32 AI055449 to J.M.). Funding Information: Potential conflicts of interest. B.E.M. has received grant support form Johnson \& Johnson, Astellas, and Intercell and has served as a consultant for Astellas, Theravance, Cubist, Targanta, Johnson \& Johnson, and Pfizer. C.A.A. has received grant support from Pfizer. H.T. is on the speaker{\textquoteright}s bureau of GlaxoSmithKline. All other authors: no conflicts. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

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Failure of daptomycin monotherapy for endocarditis caused by an Enterococcus faecium strain with vancomycin-resistant and vancomycin-susceptible subpopulations and evidence of in vivo loss of the vanA gene cluster

Abstract

ASJC Scopus subject areas

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