Failure of daptomycin monotherapy for endocarditis caused by an Enterococcus faecium strain with vancomycin-resistant and vancomycin-susceptible subpopulations and evidence of in vivo loss of the vanA gene cluster

Cesar A. Arias, Harrys A. Torres, Kavindra Singh, Diana Panesso, Judson Moore, Audrey Wanger, Barbara E. Murray

Research output: Contribution to journalArticlepeer-review

76 Scopus citations

Abstract

A patient with native valve endocarditis caused by a vancomycin "heteroresistant" strain of Enterococcus faecium experienced failure of daptomycin monotherapy without evidence of daptomycin resistance. The infecting organism exhibited in vivo emergence of a vancomycin-susceptible subpopulation lacking vanA. Treatment with a combination of high-dose daptomycin, gentamicin, and high-dose ampicillin cleared the infection.

Original languageEnglish (US)
Pages (from-to)1343-1346
Number of pages4
JournalClinical Infectious Diseases
Volume45
Issue number10
DOIs
StatePublished - Nov 15 2007

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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