TY - JOUR
T1 - Factors predicting outcome after salvage treatment for stage IV oral squamous cell carcinoma
T2 - Evidence of the potential importance of the cyclooxygenase-2-prostaglandin E2 pathway
AU - Kekatpure, Vikram D.
AU - Singh, Mandeep
AU - Selvam, Sumithra
AU - Shetkar, Girish
AU - Hedne, Naveen C.
AU - Trivedi, Nirav P.
AU - Siddappa, Gangotri
AU - Govindan, Sindhu V.
AU - Suresh, Amritha
AU - Rangarajan, Bharath
AU - Dannenberg, Andrew J.
AU - Kuriakose, Moni Abraham
N1 - Publisher Copyright:
© 2014 Wiley Periodicals, Inc.
PY - 2015/8
Y1 - 2015/8
N2 - Background We determined the clinicopathological factors that predicted outcome after salvage treatment for stage IV oral squamous cell carcinoma (OSCC). Additionally, the prognostic significance of the cyclooxygenase-2 (COX-2)/microsomal prostaglandin-E synthase-1 (mPGES-1) pathway was evaluated. Methods Thirty-one patients who underwent salvage surgery were included. COX-2 and mPGES-1 levels were quantified by real time polymerase chain reaction (PCR). Results The 2-year disease-free and overall survival rates were 46% and 53%, respectively. Adequacy of initial treatment, tobacco smoking, and the presence of pathological risk factors were predictive of mortality. In patients who had not received chemotherapy before salvage surgery, high levels of intratumoral COX-2 and mPGES-1 were associated with poor prognosis. By contrast, high intratumoral COX-2 and mPGES-1 after chemotherapy were associated with improved outcomes. Conclusion Clinicopathological factors may inform treatment decisions in patients with stage IV OSCC. Expression patterns of COX-2 and mPGES-1 correlated with outcome and warrant further investigation.
AB - Background We determined the clinicopathological factors that predicted outcome after salvage treatment for stage IV oral squamous cell carcinoma (OSCC). Additionally, the prognostic significance of the cyclooxygenase-2 (COX-2)/microsomal prostaglandin-E synthase-1 (mPGES-1) pathway was evaluated. Methods Thirty-one patients who underwent salvage surgery were included. COX-2 and mPGES-1 levels were quantified by real time polymerase chain reaction (PCR). Results The 2-year disease-free and overall survival rates were 46% and 53%, respectively. Adequacy of initial treatment, tobacco smoking, and the presence of pathological risk factors were predictive of mortality. In patients who had not received chemotherapy before salvage surgery, high levels of intratumoral COX-2 and mPGES-1 were associated with poor prognosis. By contrast, high intratumoral COX-2 and mPGES-1 after chemotherapy were associated with improved outcomes. Conclusion Clinicopathological factors may inform treatment decisions in patients with stage IV OSCC. Expression patterns of COX-2 and mPGES-1 correlated with outcome and warrant further investigation.
KW - cyclooxygenase-2 (COX-2)
KW - microsomal prostaglandin-E synthase-1 (mPGES-1)
KW - oral cavity
KW - recurrent squamous cell carcinoma (SCC)
KW - salvage surgery
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U2 - 10.1002/hed.23721
DO - 10.1002/hed.23721
M3 - Article
C2 - 24771596
AN - SCOPUS:84948392021
VL - 37
SP - 1142
EP - 1149
JO - Head and Neck Surgery
JF - Head and Neck Surgery
SN - 1043-3074
IS - 8
ER -