Factors affecting 223Ra therapy: clinical experience after 532 cycles from a single institution

Elba C. Etchebehere, Denái R. Milton, John C. Araujo, Nancy M. Swanston, Homer A. Macapinlac, Eric M. Rohren

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Purpose: The aim of this study was to identify baseline features that predict outcome in 223Ra therapy. Methods: We retrospectively reviewed 110 patients with metastatic castration-resistant prostate cancer treated with 223Ra. End points were overall survival (OS), progression-free survival (PFS), bone event-free survival (BeFS), and bone marrow failure (BMF). The following parameters were evaluated prior to the first 223Ra cycle: serum levels of hemoglobin (Hb), prostate-specific antigen (PSA), alkaline phosphatase (ALP), Eastern Cooperative Oncology Group (ECOG) status, pain score, use of chemotherapy, and external beam radiation therapy (EBRT). During/after 223Ra we evaluated: the total number of radium cycles (RaTot), the PSA doubling time (PSADT), and the use of chemotherapy, EBRT, abiraterone, and enzalutamide. Results: A significant reduction of ALP (p < 0.001) and pain score (p = 0.041) occurred throughout the 223 Ra cycles. The risk of progression was associated with declining ECOG status [hazard ratio (HR) = 3.79; p < 0.001] and decrease in PSADT (HR = 8.22; p < 0.001). RaTot, ALP, initial ECOG status, initial pain score, and use of abiraterone were associated with OS (p ≤ 0.008), PFS (p ≤ 0.003), and BeFS (p ≤ 0.020). RaTot, ALP, initial ECOG status, and initial pain score were significantly associated with BMF (p ≤ 0.001) as well as Hb (p < 0.001) and EBRT (p = 0.009). On multivariable analysis, only RaTot and abiraterone remained significantly associated with OS (p < 0.001; p = 0.033, respectively), PFS (p < 0.001; p = 0.041, respectively), and BeFS (p < 0.001; p = 0.019, respectively). Additionally, RaTot (p = 0.027) and EBRT (p = 0.013) remained significantly associated with BMF. Conclusion: Concomitant use of abiraterone and 223Ra seems to have a beneficial effect, while the EBRT may increase the risk of BMF.

Original languageEnglish (US)
Pages (from-to)8-20
Number of pages13
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume43
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • Abiraterone
  • Bone marrow failure
  • External beam radiation therapy
  • PSA
  • Prostate cancer
  • Ra

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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