Extreme hypercholesterolemia in cholestatic sarcoidosis due to lipoprotein X: Exploring the cholesterol gap

Ahmad Yehya; Rongrong Huang; David W. Bernard; Antonio Gotto; Richard J. Robbins

doi:10.1016/j.jecr.2018.08.002

Extreme hypercholesterolemia in cholestatic sarcoidosis due to lipoprotein X: Exploring the cholesterol gap

Ahmad Yehya, Rongrong Huang, David W. Bernard, Antonio Gotto, Richard J. Robbins

Research output: Contribution to journal › Article

1 Scopus citations

Abstract

Lipoprotein-X (LpX) is a rare lipid particle that can affect lipid analysis and interpretation. Case reports of LpX syndrome have been described scarcely. LpX has been linked to diseases associated with cholangiopathy and thus, in such instances, hyperlipidemia can be falsely attributed to an elevated LDL-cholesterol component or to an unknown lipid moiety. The management of LpX syndrome is completely different than that of classic hypercholesterolemia. This article describes a case of LpX syndrome and provides a review of similar cases in the literature. This review also discusses the technical measurement of LpX, management expectations and sequelae of the disease.

Original language	English (US)
Pages (from-to)	11-13
Number of pages	3
Journal	Journal of Clinical and Translational Endocrinology: Case Reports
Volume	10
DOIs	https://doi.org/10.1016/j.jecr.2018.08.002
State	Published - Dec 2018

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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title = "Extreme hypercholesterolemia in cholestatic sarcoidosis due to lipoprotein X: Exploring the cholesterol gap",

abstract = "Lipoprotein-X (LpX) is a rare lipid particle that can affect lipid analysis and interpretation. Case reports of LpX syndrome have been described scarcely. LpX has been linked to diseases associated with cholangiopathy and thus, in such instances, hyperlipidemia can be falsely attributed to an elevated LDL-cholesterol component or to an unknown lipid moiety. The management of LpX syndrome is completely different than that of classic hypercholesterolemia. This article describes a case of LpX syndrome and provides a review of similar cases in the literature. This review also discusses the technical measurement of LpX, management expectations and sequelae of the disease.",

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T2 - Exploring the cholesterol gap

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AU - Huang, Rongrong

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AU - Gotto, Antonio

AU - Robbins, Richard J.

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AB - Lipoprotein-X (LpX) is a rare lipid particle that can affect lipid analysis and interpretation. Case reports of LpX syndrome have been described scarcely. LpX has been linked to diseases associated with cholangiopathy and thus, in such instances, hyperlipidemia can be falsely attributed to an elevated LDL-cholesterol component or to an unknown lipid moiety. The management of LpX syndrome is completely different than that of classic hypercholesterolemia. This article describes a case of LpX syndrome and provides a review of similar cases in the literature. This review also discusses the technical measurement of LpX, management expectations and sequelae of the disease.

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