Extrathoracic tuberculosis lymphadenitis in adult HIV seronegative patients: A population-based analysis in Houston, Texas, USA

Omar Y. Gonzalez, L. D. Teeter, B. T. Thanh, James M. Musser, Edward A. Graviss

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

OBJECTIVE: To evaluate the covariates associated with extrathoracic tuberculosis lymphadenitis (ETBL) among adult HIV-seronegative patients. METHODS: Enrollees were interviewed for TB risk assessment, their medical records were reviewed, and their Mycobacterium tuberculosis isolates underwent molecular characterization. Between 1 October 1995 and 30 September 1999, HIV-negative patients with ETBL were compared with other HIV-negative TB patients. RESULTS: We identified 73 ETBL cases (5 %) out of a total of 1371 adult HIV-negative enrollees. Significant variables predicting ETBL in the univariate analysis included age <45 years, female sex, Asian ethnicity, foreign birth, BCG vaccination, and infection with a M. tuberculosis isolate identified in major genetic group 1. Further analysis by birth country revealed increased ETBL risk for persons from countries other than the Americas and with a TB incidence >25 per 100 000 per year. The multivariate model demonstrated increased risk for ETBL for patients of female sex (OR = 2.6, P < 0.01) and birth in Africa or South-east Asia (OR = 4.8; P = 0.03 and OR = 33.6; P = 0.01, respectively). CONCLUSIONS: In adult HIV-negative patients, ETBL occurs more frequently in females and in immigrants from countries other than the Americas; persons from India, South-east Asia and the Eastern Mediterranean exhibited the highest risk among these regions.

Original languageEnglish (US)
Pages (from-to)987-993
Number of pages7
JournalInternational Journal of Tuberculosis and Lung Disease
Volume7
Issue number10
StatePublished - Oct 1 2003

Keywords

  • Extra-pulmonary tuberculosis
  • Mycobacterium tuberculosis
  • Tuberculosis lymphadenitis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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