Extrapulmonary neoplasms in lung cancer screening

Myrna C.B. Godoy, Charles S. White, Jeremy J. Erasmus, Carol C. Wu, Mylene T. Truong, Reginald F. Munden, Caroline Chiles

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

A significant reduction in lung cancer specific mortality rate was demonstrated by the National Lung Screening Trial (NLST) in participants who had annual low-dose computed tomography (LDCT) screening. In addition to early detection of lung cancer, lung cancer screening (LCS) provides an opportunity to detect cardiovascular disease, pulmonary disease (such as chronic obstructive pulmonary disease and interstitial lung disease), and extrapulmonary neoplasms, such as thyroid, breast, kidney, liver, esophageal, pancreatic and mediastinal tumors. Considering the fact that 22.3% of the certified deaths in the computed tomography (CT) arm of the NLST trial were due to extrapulmonary malignancies, compared to 22.9% of deaths from lung cancer, it is possible that early diagnosis and treatment of clinically significant incidental findings may further decrease morbidity and mortality in screening participants. In this article we review prevalence, clinical relevance and management of incidentally detected extrapulmonary malignancies.

Original languageEnglish (US)
Pages (from-to)368-375
Number of pages8
JournalTranslational Lung Cancer Research
Volume7
Issue number3
DOIs
StatePublished - Jun 1 2018

Keywords

  • Computed tomography (CT)
  • Incidental findings (IFs)
  • Low-dose computed tomography (LDCT)
  • Lung cancer
  • Neoplasm
  • Screening

ASJC Scopus subject areas

  • Oncology

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