TY - GEN
T1 - Extraction of neurite structures for high throughput imaging screening of neuron based assays
AU - Zhang, Yong
AU - Zhou, Xiaobo
AU - Wong, Stephen T.C.
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2006
Y1 - 2006
N2 - Neuron image analysis has recently emerged as a critical component for enabling quantitative systems neurobiology and high throughput drug screening. In this paper, we present a new algorithm for fast and automatic extraction of neurite structures in microscopy neuron images. The algorithm is based on novel methods for soma segmentation, seed point detection, recursive center line detection, and 2D curve smoothing. The algorithm is fully automatic without any human interaction while robust enough for processing images of poor quality, e.g., low contrast or low signal-to-noise ratio. It can be used to extract accurately highly complex neunte structures. All these advantages make the proposed algorithm suitable for increasingly demanding and complex image analysis tasks in systems biology and drug screening.
AB - Neuron image analysis has recently emerged as a critical component for enabling quantitative systems neurobiology and high throughput drug screening. In this paper, we present a new algorithm for fast and automatic extraction of neurite structures in microscopy neuron images. The algorithm is based on novel methods for soma segmentation, seed point detection, recursive center line detection, and 2D curve smoothing. The algorithm is fully automatic without any human interaction while robust enough for processing images of poor quality, e.g., low contrast or low signal-to-noise ratio. It can be used to extract accurately highly complex neunte structures. All these advantages make the proposed algorithm suitable for increasingly demanding and complex image analysis tasks in systems biology and drug screening.
UR - http://www.scopus.com/inward/record.url?scp=37649029424&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=37649029424&partnerID=8YFLogxK
U2 - 10.1109/LSSA.2006.250391
DO - 10.1109/LSSA.2006.250391
M3 - Conference contribution
AN - SCOPUS:37649029424
SN - 1424402786
SN - 9781424402786
T3 - 2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006
BT - 2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006
T2 - 2006 IEEE/NLM Life Science Systems and Applications Workshop, LiSA 2006
Y2 - 13 July 2006 through 14 July 2006
ER -