Extracorporeal photopheresis for the treatment of autoimmune diseases

Jill Adamski; Theresa Kinard; Tina Ipe; Laura Cooling

doi:10.1016/j.transci.2015.02.005

Extracorporeal photopheresis for the treatment of autoimmune diseases

Jill Adamski, Theresa Kinard, Tina Ipe, Laura Cooling

Department of Pathology & Genomic Medicine

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

The immune system is tasked with the unique challenge of recognizing foreign pathogens and damaged cells while at the same time preserving and protecting the integrity of "self". When this process fails, severe consequences including cancer and autoimmunity are the end result. Current therapies aimed at treating autoimmune disorders result in generalized immunosuppression and place the patient at increased risk for infection and malignancy. ECP is a potential therapeutic intervention that recapitulates natural physiologic processes of tolerance induction to restore immune homeostasis. Several clinical trials suggest that ECP may be used to treat a broad spectrum of autoimmune diseases.

Original language	English (US)
Pages (from-to)	171-182
Number of pages	12
Journal	Transfusion and Apheresis Science
Volume	52
Issue number	2
DOIs	https://doi.org/10.1016/j.transci.2015.02.005
State	Published - Apr 1 2015

Keywords

Autoimmune
ECP
Photopheresis

ASJC Scopus subject areas

Hematology

Access to Document

10.1016/j.transci.2015.02.005

Cite this

@article{d894652c2540436a8a05ba84437680e9,

title = "Extracorporeal photopheresis for the treatment of autoimmune diseases",

abstract = "The immune system is tasked with the unique challenge of recognizing foreign pathogens and damaged cells while at the same time preserving and protecting the integrity of {"}self{"}. When this process fails, severe consequences including cancer and autoimmunity are the end result. Current therapies aimed at treating autoimmune disorders result in generalized immunosuppression and place the patient at increased risk for infection and malignancy. ECP is a potential therapeutic intervention that recapitulates natural physiologic processes of tolerance induction to restore immune homeostasis. Several clinical trials suggest that ECP may be used to treat a broad spectrum of autoimmune diseases.",

keywords = "Autoimmune, ECP, Photopheresis",

author = "Jill Adamski and Theresa Kinard and Tina Ipe and Laura Cooling",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

month = apr,

day = "1",

doi = "10.1016/j.transci.2015.02.005",

language = "English (US)",

volume = "52",

pages = "171--182",

journal = "Transfusion and Apheresis Science",

issn = "1473-0502",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - Extracorporeal photopheresis for the treatment of autoimmune diseases

AU - Adamski, Jill

AU - Kinard, Theresa

AU - Ipe, Tina

AU - Cooling, Laura

PY - 2015/4/1

Y1 - 2015/4/1

N2 - The immune system is tasked with the unique challenge of recognizing foreign pathogens and damaged cells while at the same time preserving and protecting the integrity of "self". When this process fails, severe consequences including cancer and autoimmunity are the end result. Current therapies aimed at treating autoimmune disorders result in generalized immunosuppression and place the patient at increased risk for infection and malignancy. ECP is a potential therapeutic intervention that recapitulates natural physiologic processes of tolerance induction to restore immune homeostasis. Several clinical trials suggest that ECP may be used to treat a broad spectrum of autoimmune diseases.

AB - The immune system is tasked with the unique challenge of recognizing foreign pathogens and damaged cells while at the same time preserving and protecting the integrity of "self". When this process fails, severe consequences including cancer and autoimmunity are the end result. Current therapies aimed at treating autoimmune disorders result in generalized immunosuppression and place the patient at increased risk for infection and malignancy. ECP is a potential therapeutic intervention that recapitulates natural physiologic processes of tolerance induction to restore immune homeostasis. Several clinical trials suggest that ECP may be used to treat a broad spectrum of autoimmune diseases.

KW - Autoimmune

KW - ECP

KW - Photopheresis

UR - http://www.scopus.com/inward/record.url?scp=84930477064&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930477064&partnerID=8YFLogxK

U2 - 10.1016/j.transci.2015.02.005

DO - 10.1016/j.transci.2015.02.005

M3 - Review article

C2 - 25886694

AN - SCOPUS:84930477064

SN - 1473-0502

VL - 52

SP - 171

EP - 182

JO - Transfusion and Apheresis Science

JF - Transfusion and Apheresis Science

IS - 2

ER -

Extracorporeal photopheresis for the treatment of autoimmune diseases

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this