TY - JOUR
T1 - Extracorporeal membrane oxygenation as a bridge to cardiac transplantation in children
AU - Ishino, Kozo
AU - Weng, Yuguo
AU - Alexi-Meskishvili, Vladimir
AU - Loebe, Matthias
AU - Uhlemann, Frank
AU - Lange, Peter E.
AU - Hetzer, Roland
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 1996
Y1 - 1996
N2 - The feasibility and efficacy of extracorporeal membrane oxygenation (ECMO) as a bridge to cardiac transplantation was examined in 6 pediatric patients who suffered irreversible myocardial failure after undergoing surgery for congenital heart defects. The mean time of ECMO support was 260.5 h, range, 101-402 h. Three patients underwent transplantation, 2 of whom are long-term survivors. Progressive hypotension as a result of capillary leak syndrome precluded further ECMO support in the other 3 patients. Overall, 2 of the 6 patients survived. Major complications were encountered in 4 patients including bleeding in 2, a seizure in 1, and renal failure in 3, 2 of whom recovered renal function after transplantation. Infection did not occur in any of the 6 patients. Exchanging ECMO components was performed with no difficulties; these exchanges included a centrifugal pump once for 2 patients and a membrane oxygenator once for 3 patients. Our results indicate that ECMO can safely keep critically ill pediatric transplant candidates alive for more than 1 week with a low incidence of multiple organ failure.
AB - The feasibility and efficacy of extracorporeal membrane oxygenation (ECMO) as a bridge to cardiac transplantation was examined in 6 pediatric patients who suffered irreversible myocardial failure after undergoing surgery for congenital heart defects. The mean time of ECMO support was 260.5 h, range, 101-402 h. Three patients underwent transplantation, 2 of whom are long-term survivors. Progressive hypotension as a result of capillary leak syndrome precluded further ECMO support in the other 3 patients. Overall, 2 of the 6 patients survived. Major complications were encountered in 4 patients including bleeding in 2, a seizure in 1, and renal failure in 3, 2 of whom recovered renal function after transplantation. Infection did not occur in any of the 6 patients. Exchanging ECMO components was performed with no difficulties; these exchanges included a centrifugal pump once for 2 patients and a membrane oxygenator once for 3 patients. Our results indicate that ECMO can safely keep critically ill pediatric transplant candidates alive for more than 1 week with a low incidence of multiple organ failure.
KW - Bridge
KW - Centrifugal pump
KW - Congenital heart defects
KW - Extracorporeal oxygenation
KW - Heart transplantation
KW - Renal failure
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U2 - 10.1111/j.1525-1594.1996.tb04513.x
DO - 10.1111/j.1525-1594.1996.tb04513.x
M3 - Article
C2 - 8817988
AN - SCOPUS:0030018372
VL - 20
SP - 728
EP - 732
JO - Artificial Organs
JF - Artificial Organs
SN - 0160-564X
IS - 5
ER -