Extracellular vesicle therapeutics from plasma and adipose tissue

Dalila Iannotta, Man Yang, Christian Celia, Luisa Di Marzio, Joy Wolfram

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Extracellular vesicles (EVs) are cell-released lipid-bilayer nanoparticles that contain biologically active cargo involved in physiological and pathological intercellular communication. In recent years, the therapeutic potential of EVs has been explored in various disease models. In particular, mesenchymal stromal cell-derived EVs have been shown to exert anti-inflammatory, anti-oxidant, anti-apoptotic, and pro-angiogenic properties in cardiovascular, metabolic and orthopedic conditions. However, a major drawback of EV-based therapeutics is scale-up issues due to extensive cell culture requirements and inefficient isolation protocols. An emerging alternative approach to time-consuming and costly cell culture expansion is to obtain therapeutic EVs directly from the body, for example, from plasma and adipose tissue. This review discusses isolation methods and therapeutic applications of plasma and adipose tissue-derived EVs, highlighting advantages and disadvantages compared to cell culture-derived ones.

Original languageEnglish (US)
Article number101159
JournalNano Today
Volume39
DOIs
StatePublished - Aug 2021

Keywords

  • Adipose tissue
  • Extracellular vesicles
  • Isolation methods
  • Plasma
  • Therapeutic

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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