Extracellular vesicle therapeutics for liver disease

David A. Borrelli; Kiera Yankson; Neha Shukla; George Vilanilam; Taylor Ticer; Joy Wolfram

doi:10.1016/j.jconrel.2018.01.022

Extracellular vesicle therapeutics for liver disease

David A. Borrelli, Kiera Yankson, Neha Shukla, George Vilanilam, Taylor Ticer, Joy Wolfram

Research output: Contribution to journal › Review article › peer-review

60 Scopus citations

Abstract

Extracellular vesicles (EVs) are endogenous nanoparticles that play important roles in intercellular communication. Unmodified and engineered EVs can be utilized for therapeutic purposes. For instance, mesenchymal stem cell (MSC)-derived EVs have shown promise for tissue repair, while drug-loaded EVs have the potential to be used for cancer treatment. The liver is an ideal target for EV therapy due to the intrinsic regenerative capacity of hepatic tissue and the tropism of systemically injected nanovesicles for this organ. This review will give an overview of the potential of EV therapeutics in liver disease. Specifically, the mechanisms by which MSC-EVs induce liver repair will be covered. Moreover, the use of drug-loaded EVs for the treatment of hepatocellular carcinoma will also be discussed. Although there are several challenges associated with the clinical translation of EVs, these biological nanoparticles represent a promising new therapeutic modality for liver disease.

Original language	English (US)
Pages (from-to)	86-98
Number of pages	13
Journal	Journal of Controlled Release
Volume	273
DOIs	https://doi.org/10.1016/j.jconrel.2018.01.022
State	Published - Mar 10 2018

Keywords

Exosome
Extracellular vesicle
Liver
Mesenchymal stem cell
Nanovesicle

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/j.jconrel.2018.01.022

Cite this

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title = "Extracellular vesicle therapeutics for liver disease",

abstract = "Extracellular vesicles (EVs) are endogenous nanoparticles that play important roles in intercellular communication. Unmodified and engineered EVs can be utilized for therapeutic purposes. For instance, mesenchymal stem cell (MSC)-derived EVs have shown promise for tissue repair, while drug-loaded EVs have the potential to be used for cancer treatment. The liver is an ideal target for EV therapy due to the intrinsic regenerative capacity of hepatic tissue and the tropism of systemically injected nanovesicles for this organ. This review will give an overview of the potential of EV therapeutics in liver disease. Specifically, the mechanisms by which MSC-EVs induce liver repair will be covered. Moreover, the use of drug-loaded EVs for the treatment of hepatocellular carcinoma will also be discussed. Although there are several challenges associated with the clinical translation of EVs, these biological nanoparticles represent a promising new therapeutic modality for liver disease.",

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author = "Borrelli, {David A.} and Kiera Yankson and Neha Shukla and George Vilanilam and Taylor Ticer and Joy Wolfram",

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T1 - Extracellular vesicle therapeutics for liver disease

AU - Borrelli, David A.

AU - Yankson, Kiera

AU - Shukla, Neha

AU - Vilanilam, George

AU - Ticer, Taylor

AU - Wolfram, Joy

PY - 2018/3/10

Y1 - 2018/3/10

N2 - Extracellular vesicles (EVs) are endogenous nanoparticles that play important roles in intercellular communication. Unmodified and engineered EVs can be utilized for therapeutic purposes. For instance, mesenchymal stem cell (MSC)-derived EVs have shown promise for tissue repair, while drug-loaded EVs have the potential to be used for cancer treatment. The liver is an ideal target for EV therapy due to the intrinsic regenerative capacity of hepatic tissue and the tropism of systemically injected nanovesicles for this organ. This review will give an overview of the potential of EV therapeutics in liver disease. Specifically, the mechanisms by which MSC-EVs induce liver repair will be covered. Moreover, the use of drug-loaded EVs for the treatment of hepatocellular carcinoma will also be discussed. Although there are several challenges associated with the clinical translation of EVs, these biological nanoparticles represent a promising new therapeutic modality for liver disease.

AB - Extracellular vesicles (EVs) are endogenous nanoparticles that play important roles in intercellular communication. Unmodified and engineered EVs can be utilized for therapeutic purposes. For instance, mesenchymal stem cell (MSC)-derived EVs have shown promise for tissue repair, while drug-loaded EVs have the potential to be used for cancer treatment. The liver is an ideal target for EV therapy due to the intrinsic regenerative capacity of hepatic tissue and the tropism of systemically injected nanovesicles for this organ. This review will give an overview of the potential of EV therapeutics in liver disease. Specifically, the mechanisms by which MSC-EVs induce liver repair will be covered. Moreover, the use of drug-loaded EVs for the treatment of hepatocellular carcinoma will also be discussed. Although there are several challenges associated with the clinical translation of EVs, these biological nanoparticles represent a promising new therapeutic modality for liver disease.

KW - Exosome

KW - Extracellular vesicle

KW - Liver

KW - Mesenchymal stem cell

KW - Nanovesicle

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DO - 10.1016/j.jconrel.2018.01.022

M3 - Review article

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JO - Journal of Controlled Release

JF - Journal of Controlled Release

SN - 0168-3659

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Extracellular vesicle therapeutics for liver disease

Abstract

Keywords

ASJC Scopus subject areas

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