Extracellular superoxide dismutase and cardiovascular disease

Tohru Fukai; Rodney J. Folz; Ulf Landmesser; David G. Harrison

doi:10.1016/S0008-6363(02)00328-0

Extracellular superoxide dismutase and cardiovascular disease

Tohru Fukai, Rodney J. Folz, Ulf Landmesser, David G. Harrison

Research output: Contribution to journal › Review article › peer-review

304 Scopus citations

Abstract

Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O₂^•-), have been implicated in the pathogenesis of many cardiovascular diseases, including atherosclerosis, hypertension, diabetes, and in endothelial dysfunction by decreasing nitric oxide (NO) bioactivity. Since the vascular levels of O₂^•- are regulated by the superoxide dismutase (SOD) enzymes, a role of SOD in the cardiovascular disease is of substantial interest. Particularly, a major form of SOD in the vessel wall is the extracellular SOD (ecSOD). This review will discuss the characteristics of ecSOD and the role of ecSOD in cardiovascular diseases.

Original language	English (US)
Pages (from-to)	239-249
Number of pages	11
Journal	Cardiovascular Research
Volume	55
Issue number	2
DOIs	https://doi.org/10.1016/S0008-6363(02)00328-0
State	Published - 2002

Keywords

Atherosclerosis
Endothelial function
Free radicals
Hypertension
Ischemia
Nitric oxide
Reperfusion

ASJC Scopus subject areas

General Medicine

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10.1016/S0008-6363(02)00328-0

Cite this

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title = "Extracellular superoxide dismutase and cardiovascular disease",

abstract = "Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O2•-), have been implicated in the pathogenesis of many cardiovascular diseases, including atherosclerosis, hypertension, diabetes, and in endothelial dysfunction by decreasing nitric oxide (NO) bioactivity. Since the vascular levels of O2•- are regulated by the superoxide dismutase (SOD) enzymes, a role of SOD in the cardiovascular disease is of substantial interest. Particularly, a major form of SOD in the vessel wall is the extracellular SOD (ecSOD). This review will discuss the characteristics of ecSOD and the role of ecSOD in cardiovascular diseases.",

keywords = "Atherosclerosis, Endothelial function, Free radicals, Hypertension, Ischemia, Nitric oxide, Reperfusion",

author = "Tohru Fukai and Folz, \{Rodney J.\} and Ulf Landmesser and Harrison, \{David G.\}",

note = "Funding Information: This work was supported by the American Heart Association Scientist Development Grant award (0030180N), NIH RO-1 HL39006, NIH RO-1 HL59248, Program Project Grant HL5800, and a VA Merit Grant. We thank Dr. Masuko Ushio-Fukai for helpful discussion and support.",

year = "2002",

doi = "10.1016/S0008-6363(02)00328-0",

language = "English (US)",

volume = "55",

pages = "239--249",

journal = "Cardiovascular Research",

issn = "0008-6363",

publisher = "Oxford University Press",

number = "2",

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T1 - Extracellular superoxide dismutase and cardiovascular disease

AU - Fukai, Tohru

AU - Folz, Rodney J.

AU - Landmesser, Ulf

AU - Harrison, David G.

N1 - Funding Information: This work was supported by the American Heart Association Scientist Development Grant award (0030180N), NIH RO-1 HL39006, NIH RO-1 HL59248, Program Project Grant HL5800, and a VA Merit Grant. We thank Dr. Masuko Ushio-Fukai for helpful discussion and support.

PY - 2002

Y1 - 2002

N2 - Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O2•-), have been implicated in the pathogenesis of many cardiovascular diseases, including atherosclerosis, hypertension, diabetes, and in endothelial dysfunction by decreasing nitric oxide (NO) bioactivity. Since the vascular levels of O2•- are regulated by the superoxide dismutase (SOD) enzymes, a role of SOD in the cardiovascular disease is of substantial interest. Particularly, a major form of SOD in the vessel wall is the extracellular SOD (ecSOD). This review will discuss the characteristics of ecSOD and the role of ecSOD in cardiovascular diseases.

AB - Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O2•-), have been implicated in the pathogenesis of many cardiovascular diseases, including atherosclerosis, hypertension, diabetes, and in endothelial dysfunction by decreasing nitric oxide (NO) bioactivity. Since the vascular levels of O2•- are regulated by the superoxide dismutase (SOD) enzymes, a role of SOD in the cardiovascular disease is of substantial interest. Particularly, a major form of SOD in the vessel wall is the extracellular SOD (ecSOD). This review will discuss the characteristics of ecSOD and the role of ecSOD in cardiovascular diseases.

KW - Atherosclerosis

KW - Endothelial function

KW - Free radicals

KW - Hypertension

KW - Ischemia

KW - Nitric oxide

KW - Reperfusion

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U2 - 10.1016/S0008-6363(02)00328-0

DO - 10.1016/S0008-6363(02)00328-0

M3 - Review article

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AN - SCOPUS:0036069786

SN - 0008-6363

VL - 55

SP - 239

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JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 2

ER -

Extracellular superoxide dismutase and cardiovascular disease

Abstract

Keywords

ASJC Scopus subject areas

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