Extracellular superoxide dismutase and cardiovascular disease

Tohru Fukai, Rodney J. Folz, Ulf Landmesser, David G. Harrison

Research output: Contribution to journalReview articlepeer-review

293 Scopus citations


Excessive production and/or inadequate removal of reactive oxygen species, especially superoxide anion (O2•-), have been implicated in the pathogenesis of many cardiovascular diseases, including atherosclerosis, hypertension, diabetes, and in endothelial dysfunction by decreasing nitric oxide (NO) bioactivity. Since the vascular levels of O2•- are regulated by the superoxide dismutase (SOD) enzymes, a role of SOD in the cardiovascular disease is of substantial interest. Particularly, a major form of SOD in the vessel wall is the extracellular SOD (ecSOD). This review will discuss the characteristics of ecSOD and the role of ecSOD in cardiovascular diseases.

Original languageEnglish (US)
Pages (from-to)239-249
Number of pages11
JournalCardiovascular Research
Issue number2
StatePublished - 2002


  • Atherosclerosis
  • Endothelial function
  • Free radicals
  • Hypertension
  • Ischemia
  • Nitric oxide
  • Reperfusion

ASJC Scopus subject areas

  • Medicine(all)


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