TY - JOUR
T1 - External beam irradiation for inhibition of intimal hyperplasia following prosthetic bypass
T2 - Preliminary results
AU - Illig, Karl A.
AU - Williams, Jacqueline P.
AU - Lyden, Sean P.
AU - Hernady, Eric
AU - Soni, Arvind
AU - Davies, Mark G.
AU - Schell, Michael
AU - Okunieff, Paul
AU - Rubin, Philip
AU - Green, Richard M.
PY - 2001
Y1 - 2001
N2 - To determine whether external beam irradiation delivered immediately after graft implantation can inhibit anastomotic intimal hyperplasia (IH) 1 month following polytetrafluoroethylene (PTFE) bypass in a sheep carotid artery model, 23 sheep underwent bilateral bypass of the ligated common carotid artery with 8-mm PTFE immediately followed by a single dose of irradiation (15, 21, or 30 Gy) to one side. The 15 animals with bilaterally patent grafts were euthanized at 1 month and graft-arterial anastomoses harvested. Using computer-aided image analysis, IH areas and thicknesses were measured. Graft patency in this model was 83% at 1 month and did not differ according to treatment administered. In the control animals, IH was greatest at mid-anastomosis, but minimal within the native vessel. All three radiation doses markedly inhibited mid-anastomotic IH area and thickness. At the proximal anastomosis, 30 Gy reduced the IH area 20-fold, from 2.06 to 0.14 mm2 (p<0.0001 by ANOVA), and IH thickness 70-fold, from 29.0 to 0.4 μm (p<0.0002); similar effects were seen at the distal anastomosis. No adverse effects of radiation treatment were observed. External beam irradiation in doses of 15 to 30 Gy delivered in a single fraction immediately after operation markedly inhibits development of intimal hyperplasia 1 month following end-to-side anastomosis with PTFE in sheep.
AB - To determine whether external beam irradiation delivered immediately after graft implantation can inhibit anastomotic intimal hyperplasia (IH) 1 month following polytetrafluoroethylene (PTFE) bypass in a sheep carotid artery model, 23 sheep underwent bilateral bypass of the ligated common carotid artery with 8-mm PTFE immediately followed by a single dose of irradiation (15, 21, or 30 Gy) to one side. The 15 animals with bilaterally patent grafts were euthanized at 1 month and graft-arterial anastomoses harvested. Using computer-aided image analysis, IH areas and thicknesses were measured. Graft patency in this model was 83% at 1 month and did not differ according to treatment administered. In the control animals, IH was greatest at mid-anastomosis, but minimal within the native vessel. All three radiation doses markedly inhibited mid-anastomotic IH area and thickness. At the proximal anastomosis, 30 Gy reduced the IH area 20-fold, from 2.06 to 0.14 mm2 (p<0.0001 by ANOVA), and IH thickness 70-fold, from 29.0 to 0.4 μm (p<0.0002); similar effects were seen at the distal anastomosis. No adverse effects of radiation treatment were observed. External beam irradiation in doses of 15 to 30 Gy delivered in a single fraction immediately after operation markedly inhibits development of intimal hyperplasia 1 month following end-to-side anastomosis with PTFE in sheep.
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U2 - 10.1007/s10016-001-0004-0
DO - 10.1007/s10016-001-0004-0
M3 - Article
C2 - 11665436
AN - SCOPUS:0034786632
SN - 0890-5096
VL - 15
SP - 533
EP - 538
JO - Annals of Vascular Surgery
JF - Annals of Vascular Surgery
IS - 5
ER -