Extensive lipomatous metaplasia in bilateral macronodular adrenocortical hyperplasia

Chris Finch, Robert Davis, Luan Truong

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Objective. - We describe a case of macronodular hyperplasia with marked adrenal enlargement in which mature adipose tissue was a significant component. To our knowledge, this condition has not been reported previously. Methods. - A 42-year-old woman with newly diagnosed Cushing's syndrome underwent endoscopic bilateral adrenalectomy to remove bilateral adrenal masses. Results. - Both adrenal glands displayed features of macronodular hyperplasia with marked adrenal enlargement, and abundant mature adipose tissue was identified in some nodules of both glands. Conclusions. - Lipomatous metaplasia is histologically demonstrated in a case of macronodular hyperplasia with marked adrenal enlargement. This distinctive change may be secondary to metaplastic transformation of either stromal cells or adrenocortical cells. The presence of lipomatous metaplasia would appear to indicate adrenocortical process, since, to our knowledge, it has never before been described in the adrenal nodule.

Original languageEnglish (US)
Pages (from-to)167-169
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Volume123
Issue number2
StatePublished - Mar 2 1999

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

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