Extended-spectrum β-lactamase-producing pathogens in a children's hospital: A 5-year experience

Anne J. Blaschke, E. Kent Korgenski, Judy A. Daly, Bonnie LaFleur, Andrew T. Pavia, Carrie L. Byington

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Background: Pediatric infection with bacteria producing extended-spectrum β-lactamases (ESBLs) has not been well described. We sought to determine the proportion of isolates producing ESBLs and the incidence of infection or colonization with these organisms in our tertiary care pediatric facility over 5 years. In addition, we sought to evaluate the characteristics of children affected. Methods: We identified all Escherichia coli or Klebsiella spp cultured from children younger than 18 years of age at our facility between January 2003 and December 2007. Medical records were reviewed for affected children. Results: Of 2697 E coli, K pneumoniae, and K oxytoca cultured, 26 ESBL producers were isolated from 16 children. Rates of ESBL production among cultured isolates significantly increased, from 0.53% in the first half of the study period to 1.4% in the second. Incidence of a primary ESBL infection also increased significantly, from 0.14/10,000 patient encounters to 0.31/10,000. The majority of children infected or colonized with ESBL-producing organisms were those with chronic medical conditions, frequent hospitalizations, or a history of recurrent infection. However, 4 affected children were less than 5 months old and evaluated in an outpatient setting. Conclusion: Rates and incidence of ESBL infection increased over the study period. Whereas most patients belonged to traditional risk groups for antibiotic-resistant infection, infants in the ambulatory setting were also affected, an at-risk population not previously described.

Original languageEnglish (US)
Pages (from-to)435-441
Number of pages7
JournalAmerican Journal of Infection Control
Issue number6
StatePublished - Aug 2009

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


Dive into the research topics of 'Extended-spectrum β-lactamase-producing pathogens in a children's hospital: A 5-year experience'. Together they form a unique fingerprint.

Cite this