Expression of tumor necrosis factor alpha and interleukin 1β in jejuna of volunteers after experimental challenge with Cryptosporidium parvum correlates with exposure but not with symptoms

P. Robinson; P. C. Okhuysen; C. L. Chappell; Dorothy E. Lewis; I. Shahab; A. Janecki; Jr White

doi:10.1128/IAI.69.2.1172-1174.2001

Expression of tumor necrosis factor alpha and interleukin 1β in jejuna of volunteers after experimental challenge with Cryptosporidium parvum correlates with exposure but not with symptoms

P. Robinson, P. C. Okhuysen, C. L. Chappell, Dorothy E. Lewis, I. Shahab, A. Janecki, Jr White

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Jejunal biopsies from volunteers challenged with Cryptosporidium parvum were examined for tumor necrosis factor alpha (TNF-α) and interleukin (IL)-1β mRNA. Postchallenge biopsies from 15 of 28 (54%) volunteers expressed TNF-α; 14% expressed IL-1β. Cytokine expression did not correlate with enteric symptoms, suggesting that TNF-α and IL-1β are not key mediators of diarrhea in human cryptosporidiosis.

Original language	English (US)
Pages (from-to)	1172-1174
Number of pages	3
Journal	Infection and Immunity
Volume	69
Issue number	2
DOIs	https://doi.org/10.1128/IAI.69.2.1172-1174.2001
State	Published - 2001

ASJC Scopus subject areas

Parasitology
Microbiology
Immunology
Infectious Diseases

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10.1128/IAI.69.2.1172-1174.2001

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Robinson, P., Okhuysen, P. C., Chappell, C. L., Lewis, D. E., Shahab, I., Janecki, A., & White, J. (2001). Expression of tumor necrosis factor alpha and interleukin 1β in jejuna of volunteers after experimental challenge with Cryptosporidium parvum correlates with exposure but not with symptoms. Infection and Immunity, 69(2), 1172-1174. https://doi.org/10.1128/IAI.69.2.1172-1174.2001

Expression of tumor necrosis factor alpha and interleukin 1β in jejuna of volunteers after experimental challenge with Cryptosporidium parvum correlates with exposure but not with symptoms. / Robinson, P.; Okhuysen, P. C.; Chappell, C. L. et al.
In: Infection and Immunity, Vol. 69, No. 2, 2001, p. 1172-1174.

Research output: Contribution to journal › Article › peer-review

Robinson, P, Okhuysen, PC, Chappell, CL, Lewis, DE, Shahab, I, Janecki, A & White, J 2001, 'Expression of tumor necrosis factor alpha and interleukin 1β in jejuna of volunteers after experimental challenge with Cryptosporidium parvum correlates with exposure but not with symptoms', Infection and Immunity, vol. 69, no. 2, pp. 1172-1174. https://doi.org/10.1128/IAI.69.2.1172-1174.2001

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AU - Lewis, Dorothy E.

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AU - Janecki, A.

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Expression of tumor necrosis factor alpha and interleukin 1β in jejuna of volunteers after experimental challenge with Cryptosporidium parvum correlates with exposure but not with symptoms

Abstract

ASJC Scopus subject areas

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