Expression of the c-jun, jun-B, ets-2 and liver regeneration factor-1 (LRF-1) genes during promotion and progression of rat liver carcinogenesis in the resistant hepatocyte model

De Zhong Liao, Agneta Blanck, Jan Åke Gustafsson, Inger Porsch Hällström

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

During promotion in the RH-model, the mRNA expression of c-jun and LRF-1 was 2- to 8-fold elevated in both initiated and uninitiated rats receiving 2-AAF. The increase was more pronounced in male than in female rats, and GH treatment of male rats down-regulated the expression towards the level in females. The level in uninitiated 2-AAF-treated livers was as high as in isolated early nodules, jun-B also showed 3- to 8-fold increased expression, but without sex differences. An increased nuclear transcription of the LRF-1 and jun-B genes but not of c-jun was observed. During progression, LRF-1 and ets-2 showed a 2- to 3-fold higher expression in persistent nodules and hepatocellular carcinomas than in the corresponding surrounding liver tissues, whereas the expression of the jun genes was 3- to 4-fold increased both in lesions and in surrounding livers when compared to age-matched control rats. In conclusion, while the changes during promotion might not be connected with control of early focal growth, the increased levels of LRF-1 and ets-2 in advanced lesions might indicate that these genes could contribute to the growth advantage for persistent nodules during progression.

Original languageEnglish (US)
Pages (from-to)215-221
Number of pages7
JournalCancer Letters
Volume100
Issue number1-2
DOIs
StatePublished - Feb 27 1996

Keywords

  • AP-1
  • Experimental
  • Growth control
  • Liver neoplasms
  • Sex differentiation
  • Transcription factors

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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