Expression of the c-Ha-ras and c-mye genes in aflatoxin B1-induced hepatocellular carcinomas

Fumio Tashiro, Shigeru Morimura, Kenshi Hayashi, Reiko Makino, Hideki Kawamura, Nobuo Horikoshi, Kiyomitsu Nemoto, Koichiro Ohtsubo, Takashi Sugimura, Yoshio Ueno

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Expression and activation of several c-oncogenes in seven hepatocellular carcinomas from seven separate rats treated with aflatoxin B1 (AFB1) were examined by Northern and Southern blot analyses. Both c-Ha-ras and c-myc transcripts were elevated at high levels in all hepatomas. Moreover, in one of them, T2-1 hepatoma, the c-myc gene was amplified only in a tumor part of liver without significant rearrangement. N-ras specific transcripts were not elevated in these hepatomas. The present data suggest that the consistently increased expression or deregulation of the c-myc and c-Ha-ras genes may play an important role in the development of hepatomas induced by AFB1.

Original languageEnglish (US)
Pages (from-to)858-864
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume138
Issue number2
DOIs
StatePublished - Jul 31 1986

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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