Expression of Sox9, Mis, and Dmrt1 in the gonad of a species with temperature-dependent sex determination

Christina Shoemaker, Mary Ramsey, Joanna Queen, David Crews

Research output: Contribution to journalArticle

100 Scopus citations

Abstract

Sex determination in vertebrates, the process of forming an ovary or testis from a bipotential gonad, can be initiated by genetic or environmental factors. Elements of the downstream molecular pathways underlying these different sex-determining mechanisms have been evolutionarily conserved. We find the first evidence that Sox9 expression is preferentially organized in the testis early in the temperature-sensitive period in a species with temperature-dependent sex determination (Trachemys scripta). This pattern occurs before sexually dimorphic Mis expression and in a temporal hierarchy that is similar to mammals. Furthermore, we extend previous findings that Dmrt1 expression at early stages of sex determination has a dimorphic pattern consistent with a possible upstream role in determining the fate of the bipotential gonad.

Original languageEnglish (US)
Pages (from-to)1055-1063
Number of pages9
JournalDevelopmental Dynamics
Volume236
Issue number4
DOIs
StatePublished - Apr 2007

Keywords

  • Dmrt1
  • Mis
  • Reptile
  • Sox9
  • Temperature-dependent sex determination
  • Testis differentiation

ASJC Scopus subject areas

  • Developmental Biology

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