Expression of plasminogen activators and plasminogen activator inhibitor 1 in dedifferentiated chondrosarcoma

Carsten Häckel, Bogdan Czerniak, Alberto G. Ayala, Kathrin Radig, Albert Roessner

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

BACKGROUND. The plasminogen activator system plays an important role in different malignant tumors. These enzymes participate in the destruction of intercellular matrices and basement membranes and/or can modulate the growth potency of tumor cells and may even promote metastases. In this study, the expression of three glycoproteins that play a role in the plasminogen activator system as activators of proteolysis-urokinase type plasminogen activator (u-PA), tissue type plasminogen activator (t-PA), and plasminogen activator inhibitor type 1 (PAI-I) were studied in various components of dedifferentiated chondrosarcomas of bone. METHODS. The expression of u-PA, t- PA, and PAI-1 was investigated in 10 dedifferentiated chondrosarcomas and 14 conventional chondrosarcomas. The plasminogen activator/inhibitor glycoproteins were visualized immunohistochemically on paraffin sections and the levels of expression were assessed semiquantitatively. RESULTS. In dedifferentiated chondrosarcoma, high grade dedifferentiated components displayed strong, diffuse coexpression of u-PA, t-PA, and PAI-1. For all glycoproteins studied, the immunoreactivity was significantly increased compared with the reactions in the low grade cartilaginous component of the same tumor and conventional chondrosarcoma. In the latter, u-PA, t-PA, and PAI-1 expression was found to be enhanced at invasive foci and in regions of endochondral ossification. CONCLUSIONS. The current study documents the overexpression of u-PA, t-PA, and PAI-1 in dedifferentiated chondrosarcoma and suggests involvement of the plasminogen activator system in the biology of these tumors.

Original languageEnglish (US)
Pages (from-to)53-58
Number of pages6
JournalCancer
Volume79
Issue number1
DOIs
StatePublished - Jan 1 1997

Keywords

  • dedifferentiated chondrosarcoma
  • plasminogen activator inhibitor 1 (PAI-1)
  • tissue type plasminogen activator (t-PA)
  • urokinase type plasminogen activator (u-PA)

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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