Expression of master regulatory genes controlling skeletal development in benign cartilage and bone forming tumors

Jane Y. Dancer, Stephen P. Henry, Jolanta Bondaruk, Sangkyou Lee, Alberto G. Ayala, Benoit De Crombrugghe, Bogdan Czerniak

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Recent progress in skeletal molecular biology has led to the clarification of the transcriptional mechanisms of chondroblastic and osteoblastic lineage differentiation. Three master transcription factors-Sox9, Runx2, and Osterix-were shown to play an essential role in determining the skeletal progenitor cells' fate. The present study evaluates the expression of these factors in 4 types of benign bone tumors-chondromyxoid fibroma, chondroblastoma, osteoid osteoma, and osteoblastoma-using immunohistochemistry and tissue microarrays. Osteoid osteoma and osteoblastoma showed strong nuclear expression of Osterix and Runx2. In contrast, only a few chondroblastomas showed positive nuclear expression of Osterix. Strong nuclear expression of Sox9 was detected in all chondroblastomas, whereas nearly half of the osteoblastomas showed focal weak cytoplasmic expression of Sox9.

Original languageEnglish (US)
Pages (from-to)1788-1793
Number of pages6
JournalHuman Pathology
Volume41
Issue number12
DOIs
StatePublished - Dec 2010

Keywords

  • Benign bone tumors
  • Master regulatory proteins
  • Skeletal development

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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