Expression of IL-17B in neurons and evaluation of its possible role in the chromosome 5q-linked form of Charcot-Marie-Tooth disease

E. E. Moore, S. Presnell, U. Garrigues, A. Guilbot, E. LeGuern, D. Smith, L. Yao, T. E. Whitmore, T. Gilbert, T. D. Palmer, P. J. Horner, R. E. Kuestner

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

IL-17B is a recently identified homolog of IL-17. Northern analysis revealed that IL-17B mRNA is expressed at very high levels in spinal cord and at much lower and more variable levels in trachea, prostate, lung, small intestine, testes, adrenal, and pancreas. In developing mouse embryos IL-17B expression was first detected at day 11 and appeared to peak at day 15. In situ analysis of mouse spinal cord, dorsal root ganglia, and brain demonstrated that IL-17B mRNA is primarily expressed by the neurons. Immunohistochemical analysis of human spinal cord, dorsal root ganglia, cerebral cortex, cerebellum, and hippocampus demonstrated that IL-17B protein is primarily localized to the neuronal cell bodies and axons. Radiation hybrid mapping localized the IL-17B gene to a region on human chromosome 5q that is associated with a rare autosomal recessive form of Charcot-Marie-Tooth demyelinating disease. However, no changes were found in the coding regions, splice junctions, intron 1, or the 5′ and 3′ untranslated regions of IL-17B genes of patients affected with this disease.

Original languageEnglish (US)
Pages (from-to)141-150
Number of pages10
JournalNeuromuscular Disorders
Volume12
Issue number2
DOIs
StatePublished - 2002

Keywords

  • Charcot-Marie-Tooth disease
  • IL-17B
  • Myelin
  • Neurons

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Clinical Neurology
  • Genetics(clinical)

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