Expression of heme oxygenase-1 by endothelial cells: A protective response to injury in transplantation

M. P. Soares, S. Brouard, R. N. Smith, L. Otterbein, Augustine M K Choi , F. H. Bach

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Endothelial cells (EC) play a pivotal role in the regulation of inflammation by expressing a series of pro- and anti-inflammatory genes that are associated with the activation of these cells. The nature of these genes and the regulation of their expression may be particularly important for the outcome of immediately vascularised transplants. We refer to the set of anti-inflammatory genes that are expressed during EC activation as protective genes because they can block the expression of pro-inflammatory genes associated with EC activation and prevent EC apoptosis. In this review we discuss data that supports the hypothesis that expression of these protective genes in a transplanted organ can promote its survival. We will focus on the description of one such protective gene, heme oxygenase-1 (HO-1). The first part of the review discusses the potential role of EC activation in regulating inflammatory responses such as those associated with the rejection of transplanted organs. The second part discusses the molecular mechanisms that regulate the expression of HO-1 in EC as well as the molecular mechanism by which the expression of this gene can regulate EC activation. The third part discusses potential mechanisms by which HO-1 may contribute to suppress different phases of the rejection of transplanted organs, e.g., ischaemia reperfusion injury, acute rejection and chronic failure. In the last part we discuss the role of HO-1 in establishing long-term survival of organs that are transplanted across different species, an approach referred to as xenotransplantation.

Original languageEnglish (US)
Pages (from-to)11-27
Number of pages17
JournalExpert Opinion on Therapeutic Targets
Volume4
Issue number1
DOIs
StatePublished - Feb 1 2000

Keywords

  • acute rejection
  • apoptosis
  • arteriosclerosis
  • chronic rejection
  • endothelial cell
  • heme oxygenase-1
  • inflammation
  • ischaemia/reperfusion injury
  • protective genes
  • transplantation
  • xenotransplantation

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Fingerprint Dive into the research topics of 'Expression of heme oxygenase-1 by endothelial cells: A protective response to injury in transplantation'. Together they form a unique fingerprint.

Cite this