Expression of estrogen receptor alpha and beta during mouse embryogenesis

Josephine G. Lemmen, José L.M. Broekhof, George G.J.M. Kuiper, Jan Åke Gustafsson, Paul T. Van Der Saag, Bart Van Der Burg

Research output: Contribution to journalArticlepeer-review

129 Scopus citations


In adult mammals numerous target tissues and organs for estrogens exist. Little is known about possible target organs during embryogenesis other than the reproductive tract and the gonads. This is the first report on the expression of estrogen receptor beta (ERβ) in comparison with ERα mRNA during mouse embryogenesis. We found expression of estrogen receptor mRNA in the reproductive tract, but also in the atrial wall, brain, kidney, urethra, bladder neck, mammary gland primordium, midgut, cartilage primordia and perichondria.

Original languageEnglish (US)
Pages (from-to)163-167
Number of pages5
JournalMechanisms of Development
Issue number1-2
StatePublished - Mar 1 1999


  • Cartilage primordia
  • Estrogen receptor alpha
  • Estrogen receptor beta
  • Gonad
  • Heart
  • Kidney
  • Larynx
  • Mammary gland
  • Midgut
  • Mouse embryogenesis
  • Mullerian duct
  • Reproductive tract
  • Steroid hormone receptor
  • Wolffian duct

ASJC Scopus subject areas

  • Developmental Biology
  • Developmental Neuroscience


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