Expression of estrogen receptor alpha and beta during mouse embryogenesis

Josephine G. Lemmen; José L.M. Broekhof; George G.J.M. Kuiper; Jan Åke Gustafsson; Paul T. Van Der Saag; Bart Van Der Burg

doi:10.1016/S0925-4773(98)00223-8

Expression of estrogen receptor alpha and beta during mouse embryogenesis

Josephine G. Lemmen, José L.M. Broekhof, George G.J.M. Kuiper, Jan Åke Gustafsson, Paul T. Van Der Saag, Bart Van Der Burg

Research output: Contribution to journal › Article › peer-review

135 Scopus citations

Abstract

In adult mammals numerous target tissues and organs for estrogens exist. Little is known about possible target organs during embryogenesis other than the reproductive tract and the gonads. This is the first report on the expression of estrogen receptor beta (ERβ) in comparison with ERα mRNA during mouse embryogenesis. We found expression of estrogen receptor mRNA in the reproductive tract, but also in the atrial wall, brain, kidney, urethra, bladder neck, mammary gland primordium, midgut, cartilage primordia and perichondria.

Original language	English (US)
Pages (from-to)	163-167
Number of pages	5
Journal	Mechanisms of Development
Volume	81
Issue number	1-2
DOIs	https://doi.org/10.1016/S0925-4773(98)00223-8
State	Published - Mar 1 1999

Keywords

Cartilage primordia
Estrogen receptor alpha
Estrogen receptor beta
Gonad
Heart
Kidney
Larynx
Mammary gland
Midgut
Mouse embryogenesis
Mullerian duct
Reproductive tract
Steroid hormone receptor
Wolffian duct

ASJC Scopus subject areas

Developmental Biology
Developmental Neuroscience

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10.1016/S0925-4773(98)00223-8

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title = "Expression of estrogen receptor alpha and beta during mouse embryogenesis",

abstract = "In adult mammals numerous target tissues and organs for estrogens exist. Little is known about possible target organs during embryogenesis other than the reproductive tract and the gonads. This is the first report on the expression of estrogen receptor beta (ERβ) in comparison with ERα mRNA during mouse embryogenesis. We found expression of estrogen receptor mRNA in the reproductive tract, but also in the atrial wall, brain, kidney, urethra, bladder neck, mammary gland primordium, midgut, cartilage primordia and perichondria.",

keywords = "Cartilage primordia, Estrogen receptor alpha, Estrogen receptor beta, Gonad, Heart, Kidney, Larynx, Mammary gland, Midgut, Mouse embryogenesis, Mullerian duct, Reproductive tract, Steroid hormone receptor, Wolffian duct",

author = "Lemmen, {Josephine G.} and Broekhof, {Jos{\'e} L.M.} and Kuiper, {George G.J.M.} and Gustafsson, {Jan {\AA}ke} and {Van Der Saag}, {Paul T.} and {Van Der Burg}, Bart",

note = "Funding Information: The authors wish to thank A. Feijen and M.J. Goumans for excellent help with the in situ hybridization and analysis and F. Vervoordeldonk and J. Heinen for help with the figures. This work was supported by European Community grant PL951223 (J.{\AA}.G., B.v.d.B.), STW (J.M.B), the Swedish Medical Research Council (MFR K98-04P-12596) and Hans Ostermans Stiftelse (G.G.J.M.K).",

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doi = "10.1016/S0925-4773(98)00223-8",

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AU - Lemmen, Josephine G.

AU - Broekhof, José L.M.

AU - Kuiper, George G.J.M.

AU - Gustafsson, Jan Åke

AU - Van Der Saag, Paul T.

AU - Van Der Burg, Bart

N1 - Funding Information: The authors wish to thank A. Feijen and M.J. Goumans for excellent help with the in situ hybridization and analysis and F. Vervoordeldonk and J. Heinen for help with the figures. This work was supported by European Community grant PL951223 (J.Å.G., B.v.d.B.), STW (J.M.B), the Swedish Medical Research Council (MFR K98-04P-12596) and Hans Ostermans Stiftelse (G.G.J.M.K).

PY - 1999/3/1

Y1 - 1999/3/1

N2 - In adult mammals numerous target tissues and organs for estrogens exist. Little is known about possible target organs during embryogenesis other than the reproductive tract and the gonads. This is the first report on the expression of estrogen receptor beta (ERβ) in comparison with ERα mRNA during mouse embryogenesis. We found expression of estrogen receptor mRNA in the reproductive tract, but also in the atrial wall, brain, kidney, urethra, bladder neck, mammary gland primordium, midgut, cartilage primordia and perichondria.

AB - In adult mammals numerous target tissues and organs for estrogens exist. Little is known about possible target organs during embryogenesis other than the reproductive tract and the gonads. This is the first report on the expression of estrogen receptor beta (ERβ) in comparison with ERα mRNA during mouse embryogenesis. We found expression of estrogen receptor mRNA in the reproductive tract, but also in the atrial wall, brain, kidney, urethra, bladder neck, mammary gland primordium, midgut, cartilage primordia and perichondria.

KW - Cartilage primordia

KW - Estrogen receptor alpha

KW - Estrogen receptor beta

KW - Gonad

KW - Heart

KW - Kidney

KW - Larynx

KW - Mammary gland

KW - Midgut

KW - Mouse embryogenesis

KW - Mullerian duct

KW - Reproductive tract

KW - Steroid hormone receptor

KW - Wolffian duct

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Expression of estrogen receptor alpha and beta during mouse embryogenesis

Abstract

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