Expression, function, and clinical implications of the estrogen receptor β in human lung cancers

Yoko Omoto; Eiju Tsuchiya; Hidetaka Eguchi; Shin ichi Hayashi; Yasuhito Kobayashi; Yoko Omoto; Takao Yamori; Hirotaka Iwase; Ken Nakagawa; Yuichi Ishikawa; Margaret Warner; Jan Åke Gustafsson; Margaret Warner; Jan Åke Gustafsson

doi:10.1006/bbrc.2001.5158

Expression, function, and clinical implications of the estrogen receptor β in human lung cancers

Yoko Omoto, Eiju Tsuchiya, Hidetaka Eguchi, Shin ichi Hayashi, Yasuhito Kobayashi, Yoko Omoto, Takao Yamori, Hirotaka Iwase, Ken Nakagawa, Yuichi Ishikawa, Margaret Warner, Jan Åke Gustafsson, Margaret Warner, Jan Åke Gustafsson

Research output: Contribution to journal › Article

180 Scopus citations

Abstract

The higher frequency of human lung adenocarcinoma in females than in males, strongly suggests the involvement of gender dependent factors in the etiology of this disease. This is the first investigation of estrogen receptor (ER) β in human lung. Immunohistochemical staining revealed ERβ expression in normal lung and in atypical adenomatous hyperplasia (AAH), considered as a precancerous lesion for adenocarcinomas. Adenocarcinomas showed significantly higher expression of ERβ than squamous cell carcinomas. On the contrary, ERα expression was not detected in all cases. The functional integrity of ERβ such as the binding ability to estrogen responsive element (ERE) and transcriptional activity was confirmed using a human lung cancer cell line, RERF-LC-OK. Colony formation of this cell was significantly reduced in the presence of pure antiestrogen. We conclude that ERβ, but not ERα, is present in lung tissues with an important physiological function in normal lung. Furthermore, ERβ may play a role in growth and development of adenocarcinomas.

Original language	English (US)
Pages (from-to)	340-347
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	285
Issue number	2
DOIs	https://doi.org/10.1006/bbrc.2001.5158
State	Published - 2001

Keywords

Adenocarcinoma
Estrogen receptor β
Lung cancer

ASJC Scopus subject areas

Biochemistry
Biophysics
Molecular Biology

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Omoto, Y., Tsuchiya, E., Eguchi, H., Hayashi, S. I., Kobayashi, Y., Omoto, Y., Yamori, T., Iwase, H., Nakagawa, K., Ishikawa, Y., Warner, M., Gustafsson, J. Å., Warner, M., & Gustafsson, J. Å. (2001). Expression, function, and clinical implications of the estrogen receptor β in human lung cancers. Biochemical and Biophysical Research Communications, 285(2), 340-347. https://doi.org/10.1006/bbrc.2001.5158

Expression, function, and clinical implications of the estrogen receptor β in human lung cancers. / Omoto, Yoko; Tsuchiya, Eiju; Eguchi, Hidetaka; Hayashi, Shin ichi; Kobayashi, Yasuhito; Omoto, Yoko; Yamori, Takao; Iwase, Hirotaka; Nakagawa, Ken; Ishikawa, Yuichi; Warner, Margaret ; Gustafsson, Jan Åke; Warner, Margaret; Gustafsson, Jan Åke.

In: Biochemical and Biophysical Research Communications, Vol. 285, No. 2, 2001, p. 340-347.

Research output: Contribution to journal › Article

Omoto, Y, Tsuchiya, E, Eguchi, H, Hayashi, SI, Kobayashi, Y, Omoto, Y, Yamori, T, Iwase, H, Nakagawa, K, Ishikawa, Y, Warner, M , Gustafsson, JÅ, Warner, M & Gustafsson, JÅ 2001, 'Expression, function, and clinical implications of the estrogen receptor β in human lung cancers', Biochemical and Biophysical Research Communications, vol. 285, no. 2, pp. 340-347. https://doi.org/10.1006/bbrc.2001.5158

Omoto, Yoko ; Tsuchiya, Eiju ; Eguchi, Hidetaka ; Hayashi, Shin ichi ; Kobayashi, Yasuhito ; Omoto, Yoko ; Yamori, Takao ; Iwase, Hirotaka ; Nakagawa, Ken ; Ishikawa, Yuichi ; Warner, Margaret ; Gustafsson, Jan Åke ; Warner, Margaret ; Gustafsson, Jan Åke. / Expression, function, and clinical implications of the estrogen receptor β in human lung cancers. In: Biochemical and Biophysical Research Communications. 2001 ; Vol. 285, No. 2. pp. 340-347.

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