Exposure of Clinical MRSA Heterogeneous Strains to β-Lactams Redirects Metabolism to Optimize Energy Production through the TCA Cycle

Agriculture & Biology

• lactams 98%
• methicillin-resistant Staphylococcus aureus 88%
• tricarboxylic acid cycle 76%
• energy 41%
• metabolism 41%
• oxacillin 23%
• SOS response (genetics) 12%
• aconitate hydratase 12%
• methicillin 10%
• metabolome 10%
• infection 9%
• health services 9%
• penicillins 9%
• liquid chromatography 8%
• gas chromatography-mass spectrometry 8%
• binding proteins 7%
• mass spectrometry 7%
• biochemical pathways 7%
• inactivation 7%
• physiology 7%
• chemical derivatives 6%
• antibiotics 6%
• cell walls 6%
• genes 6%
• pathogens 5%
• synthesis 4%
• enzymes 3%

Medicine & Life Sciences

• Lactams 100%
• Citric Acid Cycle 86%
• Methicillin-Resistant Staphylococcus aureus 71%
• Oxacillin 23%
• Aconitate Hydratase 12%
• Genetics SOS Response 12%
• Penicillin-Binding Proteins 12%
• Methicillin Resistance 10%
• Gas Chromatography-Mass Spectrometry 10%
• Metabolome 9%
• Liquid Chromatography 9%
• Microarray Analysis 9%
• Cell Wall 8%
• Metabolic Networks and Pathways 8%
• Infections 8%
• Mass Spectrometry 7%
• Genes 7%
• Population 6%
• Anti-Bacterial Agents 5%
• Pressure 5%
• Costs and Cost Analysis 5%
• Delivery of Health Care 5%
• Enzymes 4%

Chemistry

• Citric Acid 67%
• Pharmacological Metabolism 54%
• Strain 48%
• Resistance 44%
• Energy 32%
• Metabolic 11%
• Oxacillin 10%
• Methicillin 10%
• Penicillin 7%
• Microarrays 7%
• Liquid Chromatography Mass Spectrometry (LCMS) 7%
• Gas Chromatography Mass Spectrometry (GCMS) 5%
• Antimicrobial Agent 4%
• Pressure 4%
• Protein 2%