Exploring Alzheimer's disease in zebrafish

Weiming Xia

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


The amyloid-β protein (Aβ)-containing neuritic plaques and hyperphosphorylated tau-containing neurofibrillary tangles are two invariable characteristics of Alzheimer's disease (AD). Three genes encoding amyloid-β protein precursor (AβPP), presenilin (PS) 1 and 2 are linked to early onset familial AD, and the apolipoprotein E (ApoE) ε4 allele is a major risk factor for sporadic AD. The zebrafish AβPP, PS, and ApoE genes have been identified, and the essential components of the γ-secretase complex that mediates cleavage of AβPP to generate Aβ have been examined in zebrafish. A transgenic zebrafish expressing mutant tau has been created, and the transgenic animals exhibit a neurodegeneration phenotype. The use of zebrafish as a model system for AD research has expanded our knowledge of Aβ and tau.

Original languageEnglish (US)
Pages (from-to)981-990
Number of pages10
JournalJournal of Alzheimer's Disease
Issue number4
StatePublished - 2010


  • Alzheimer
  • amyloid
  • secretase
  • tau
  • transgenic
  • zebrafish

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology


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