Experimental studies with111indium-labeled platelets in pulmonary embolism

H. D. Sostman, R. D. Neumann, S. S. Zoghbi, P. F. Lord, M. L. Thakur, P. Carbo, R. H. Greenspan, A. Gottschalk

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The effects of several potential modifiers on the detection of experimental pulmonary emboli by indium-111-labeled autologous platelets were studied. Contrast material did not affect embolus visualization; heparin prevented it, but its effect was not irreversible. The addition of exogenous thrombin to the experimental thrombus was not necessary for successful detection of the resulting emboli. Indium-111-oxine detected a small number of emboli without in vitro platelet labeling. Acutely embolized thrombi up to 72 hours old were readily identified by labeled platelets, but emboli older than 24 hours were almost impossible to detect. There was evidence suggesting propagation of emboli within the pulmonary arteries.

Original languageEnglish (US)
Pages (from-to)367-373
Number of pages7
JournalInvestigative Radiology
Volume17
Issue number4
DOIs
StatePublished - 1982

Keywords

  • Indium-111
  • Platelet labeling
  • Pulmonary emboli

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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