Experimental percutaneous renal embolization using BCG-saturated gelfoam

Kenneth C. Wright; Chiu Shiung Soo; Sidney Wallace; Michael W. McDonald; Alberto Ayala

doi:10.1007/BF02565408

Experimental percutaneous renal embolization using BCG-saturated gelfoam

Kenneth C. Wright, Chiu Shiung Soo, Sidney Wallace, Michael W. McDonald, Alberto Ayala

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Adult mongrel dogs (20-25 kg) were used to evaluate the administration of Bacillus Calmette-Guerin (BCG) in conjunction with total renal embolization for possible application in the management of metastatic renal cell carcinoma (RCC). Kidneys were surgically removed at 1, 2, and 3 weeks postembolization, examined grossly and microscopically, and then compared with kidneys embolized in the same manner without BCG. The procedure stimulated the reticuloendothelial system more than did renal embolization alone, and although a high dose (6×10⁸ organisms) of BCG was administered, no complications were encountered. These results warrant a clinical trial of this technique in patients with advanced RCC.

Original language	English (US)
Pages (from-to)	260-263
Number of pages	4
Journal	CardioVascular and Interventional Radiology
Volume	5
Issue number	5
DOIs	https://doi.org/10.1007/BF02565408
State	Published - Dec 1 1982

Keywords

Bacillus Calmette-Guerin, intraarterial
Kidney, experimental arterial embolization
Renal cell carcinoma

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Cardiology and Cardiovascular Medicine

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10.1007/BF02565408

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title = "Experimental percutaneous renal embolization using BCG-saturated gelfoam",

abstract = "Adult mongrel dogs (20-25 kg) were used to evaluate the administration of Bacillus Calmette-Guerin (BCG) in conjunction with total renal embolization for possible application in the management of metastatic renal cell carcinoma (RCC). Kidneys were surgically removed at 1, 2, and 3 weeks postembolization, examined grossly and microscopically, and then compared with kidneys embolized in the same manner without BCG. The procedure stimulated the reticuloendothelial system more than did renal embolization alone, and although a high dose (6×108 organisms) of BCG was administered, no complications were encountered. These results warrant a clinical trial of this technique in patients with advanced RCC.",

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AU - Wright, Kenneth C.

AU - Soo, Chiu Shiung

AU - Wallace, Sidney

AU - McDonald, Michael W.

AU - Ayala, Alberto

PY - 1982/12/1

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AB - Adult mongrel dogs (20-25 kg) were used to evaluate the administration of Bacillus Calmette-Guerin (BCG) in conjunction with total renal embolization for possible application in the management of metastatic renal cell carcinoma (RCC). Kidneys were surgically removed at 1, 2, and 3 weeks postembolization, examined grossly and microscopically, and then compared with kidneys embolized in the same manner without BCG. The procedure stimulated the reticuloendothelial system more than did renal embolization alone, and although a high dose (6×108 organisms) of BCG was administered, no complications were encountered. These results warrant a clinical trial of this technique in patients with advanced RCC.

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KW - Renal cell carcinoma

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Experimental percutaneous renal embolization using BCG-saturated gelfoam

Abstract

Keywords

ASJC Scopus subject areas

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