Experimental fusarial hyalohyphomycosis in a murine model

Catherine Legrand, Elias Anaissie, Ray Hashem, Paul Nelson, Gerald P. Bodey, Jae Ro

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The pathogenicity of two clinical strains of Fusarium solani was studied in normal and transiently neutropenic outbred CF1 and CD1 male mice. Three inocula (5 × 105, 1 × 106, and 5 × 106 spores/animal) were tested. Groups of 10 mice each were injected with a single intravenous dose of one inoculum. Mortality correlated with the dose of inoculum, as survival was significantly shorter in mice injected with 5 × 106 cfu/mouse than in mice that received 1 × 106 or 5 × 105 cfu/mouse (P < .001). Necrotizing abscesses with acute branching septate hyphae, neutrophil and macrophage infiltration, and hemorrhage were observed. The median survival of neutropenic mice was shorter than that of normal mice (P < .001). Neutropenic mice did not show evidence of an inflammatory cellular reaction and exhibited significantly higher numbers of fungi per gram of infected tissue (P < .001). Intact host defenses in normal mice were able to confine the infection to the kidneys after initial dissemination. In contrast, disseminated infection persisted in most organs in immunosuppressed animals.

Original languageEnglish (US)
Pages (from-to)944-948
Number of pages5
JournalJournal of Infectious Diseases
Volume164
Issue number5
DOIs
StatePublished - Jan 1 1991

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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