TY - JOUR
T1 - Experimental fusarial hyalohyphomycosis in a murine model
AU - Legrand, Catherine
AU - Anaissie, Elias
AU - Hashem, Ray
AU - Nelson, Paul
AU - Bodey, Gerald P.
AU - Ro, Jae
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1991/11
Y1 - 1991/11
N2 - The pathogenicity of two clinical strains of Fusarium solani was studied in normal and transiently neutropenic outbred CF1 and CD1 male mice. Three inocula (5 × 105, 1 × 106, and 5 × 106 spores/animal) were tested. Groups of 10 mice each were injected with a single intravenous dose of one inoculum. Mortality correlated with the dose of inoculum, as survival was significantly shorter in mice injected with 5 × 106 cfu/mouse than in mice that received 1 × 106 or 5 × 105 cfu/mouse (P < .001). Necrotizing abscesses with acute branching septate hyphae, neutrophil and macrophage infiltration, and hemorrhage were observed. The median survival of neutropenic mice was shorter than that of normal mice (P < .001). Neutropenic mice did not show evidence of an inflammatory cellular reaction and exhibited significantly higher numbers of fungi per gram of infected tissue (P < .001). Intact host defenses in normal mice were able to confine the infection to the kidneys after initial dissemination. In contrast, disseminated infection persisted in most organs in immunosuppressed animals.
AB - The pathogenicity of two clinical strains of Fusarium solani was studied in normal and transiently neutropenic outbred CF1 and CD1 male mice. Three inocula (5 × 105, 1 × 106, and 5 × 106 spores/animal) were tested. Groups of 10 mice each were injected with a single intravenous dose of one inoculum. Mortality correlated with the dose of inoculum, as survival was significantly shorter in mice injected with 5 × 106 cfu/mouse than in mice that received 1 × 106 or 5 × 105 cfu/mouse (P < .001). Necrotizing abscesses with acute branching septate hyphae, neutrophil and macrophage infiltration, and hemorrhage were observed. The median survival of neutropenic mice was shorter than that of normal mice (P < .001). Neutropenic mice did not show evidence of an inflammatory cellular reaction and exhibited significantly higher numbers of fungi per gram of infected tissue (P < .001). Intact host defenses in normal mice were able to confine the infection to the kidneys after initial dissemination. In contrast, disseminated infection persisted in most organs in immunosuppressed animals.
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U2 - 10.1093/infdis/164.5.944
DO - 10.1093/infdis/164.5.944
M3 - Article
C2 - 1940473
AN - SCOPUS:0025931051
SN - 0022-1899
VL - 164
SP - 944
EP - 948
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 5
ER -