Experimental Cholesterol Granuloma

Thomas S. Main, Tadao Shimada, David J. Lim

Research output: Contribution to journalArticlepeer-review

68 Scopus citations


Cholesterol granulomas were produced in the mastoid cavity of the squirrel monkey by obstructing the eustachian tube with silicone-rubber (Silastic) sponges. It was noted that these granulomas developed only in the mastoid cells, which is suggestive that isolation of hemorrhage in a small area without ventilation is an important factor in the genesis of cholesterol granulomas. Our experiment favors the concept that hemorrhage in mastoid air cells, possibly due to negative pressure, has a vital role in the pathogenesis of this disease.

Original languageEnglish (US)
Pages (from-to)356-359
Number of pages4
JournalArchives of Otolaryngology
Issue number4
StatePublished - Apr 1970

ASJC Scopus subject areas

  • Otorhinolaryngology


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